Document Detail

Infarct size and post-infarct inflammation determine the risk of cardiac rupture in mice.
MedLine Citation:
PMID:  19195725     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/OBJECTIVES: Infarct size (IS) is a determinant of pathophysiological events after myocardial infarction (MI), but its relation to the risk of cardiac rupture remains undefined. METHODS: MI was induced in 129sv and C57Bl/6 mice. Left ventricular (LV) remodelling was examined by echocardiography prior to the onset of rupture. Changes in muscle tensile strength and expression of inflammatory factors were determined. Autopsy was performed and IS measured. RESULTS: Rupture incidence was higher in 129sv than C57Bl/6 mice (62% vs. 33%, P<0.001). Rupture occurred in mice with IS over a threshold, which was smaller in 129sv than C57Bl/6 mice (20% vs. 30%). 129sv mice with IS>30% had a higher incidence of rupture than those with IS 20-30%. Echocardiography revealed IS-dependent LV remodelling and dysfunction and 129sv mice had a better-preserved function compared with C57Bl/6 counterparts. 129sv but not C57Bl/6 mice that subsequently developed rupture showed more severe regional dysfunction and remodelling compared with IS-matched non-ruptured hearts. Tensile strength of the infarcted myocardium was reduced significantly, which was IS-related. 129sv mice had higher expression levels of inflammatory mediators in the infarcted myocardium or circulating inflammatory cells, underlying the higher risk of rupture in this strain than C57Bl/6. CONCLUSIONS: A critical IS level is necessary for post-MI rupture and IS correlates with the reduction in muscle tensile strength. Strain differences exist in global function and regional or systemic inflammation that explain the different risk of rupture or heart failure between strains. Limiting IS or minimizing inflammation would lower the risk of ventricular rupture.
Xiao-Ming Gao; Ziqiu Ming; Yidan Su; Lu Fang; Helen Kiriazis; Qi Xu; Anthony M Dart; Xiao-Jun Du
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-04
Journal Detail:
Title:  International journal of cardiology     Volume:  143     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-10-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  20-8     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
Experimental Cardiology Laboratory, Baker IDI Heart Diabetes Institute, and Alfred Heart Centre, the Alfred Hospital, Monash University, 75 Commercial Road, Prahran, Melbourne, Victoria 3004, Australia.
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MeSH Terms
Coronary Occlusion / epidemiology,  surgery,  ultrasonography
Disease Models, Animal
Gene Expression / immunology
Heart Failure / epidemiology,  immunology,  ultrasonography
Heart Rupture, Post-Infarction* / epidemiology,  immunology,  ultrasonography
Inflammation Mediators / immunology
Mice, Inbred C57BL
Myocardial Infarction* / epidemiology,  immunology,  ultrasonography
Myocarditis* / epidemiology,  immunology,  ultrasonography
Risk Factors
Severity of Illness Index*
Tensile Strength
Ventricular Remodeling / immunology
Reg. No./Substance:
0/Inflammation Mediators

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