| Infarct size and location determine development of mitral regurgitation in the sheep model. | |
| | |
MedLine Citation:
|
PMID: 9535449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: This study tests the hypothesis that neither small nor large myocardial infarctions that include the anterior papillary muscle produce mitral regurgitation in sheep. METHODS: Coronary arterial anatomy to the anterior left ventricle and papillary muscle was determined by dye injection in 41 sheep hearts and by triphenyl tetrazolium chloride in 13. Development of acute or chronic mitral regurgitation and changes in left ventricular dimensions were studied by use of transdiaphragmatic echocardiography in 21 sheep after infarction of 24% and 33% of the anterior left ventricular mass. These data were compared with previous data from large and small posterior left ventricular infarctions. RESULTS: Ligation of two diagonal arteries infarcts 24% of the left ventricular mass and 82% of the anterior papillary muscle. Ligation of both diagonals and the first circumflex branch infarcts 33% of the left ventricle and all of the anterior papillary muscle. Neither infarction causes mitral regurgitation, although left ventricular cavity dimensions increase significantly at end systole. After the smaller infarction, the left ventricular cavity enlarges 150% over 8 weeks without mitral regurgitation. CONCLUSIONS: In sheep small and large infarctions of the anterior wall that include the anterior papillary muscle do not produce either acute or chronic mitral regurgitation despite left ventricular dilatation. In contrast large posterior infarctions produce immediate mitral regurgitation owing to asymmetric annular dilatation and discoordination of papillary muscle relationships to the valve. After small posterior infarctions that include the posterior papillary muscle, mitral regurgitation develops because of annular and ventricular dilatation during remodeling. |
| | |
Authors:
|
J H Gorman; R C Gorman; T Plappert; B M Jackson; Y Hiramatsu; M G St John-Sutton; L H Edmunds |
Related Documents
:
|
12063449 - Ischemic mitral regurgitation: intraventricular papillary muscle imbrication without mi... 3982059 - Intraoperative contrast two-dimensional echocardiography. evaluation of the presence an... 17251259 - Mitral regurgitation in myocardial infarction complicated by heart failure, left ventri... 3583459 - Cross-sectional and pulsed doppler echocardiography of the atrioventricular junction of... 19196619 - Differences in echocardiographic characteristics of functional mitral regurgitation in ... 17363089 - Rest and stress echocardiographic predictors of prognosis in patients with left ventric... 9127439 - Contractile responses to histamine, serotonin, and angiotensin ii are impaired by 17 be... 1700219 - Delay of occurrence of reperfusion-induced ventricular fibrillation in the isolated rat... 8681319 - Identification, diagnosis and treatment of heart failure: could we do better? |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of thoracic and cardiovascular surgery Volume: 115 ISSN: 0022-5223 ISO Abbreviation: J. Thorac. Cardiovasc. Surg. Publication Date: 1998 Mar |
Date Detail:
|
Created Date: 1998-04-16 Completed Date: 1998-04-16 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0376343 Medline TA: J Thorac Cardiovasc Surg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 615-22 Citation Subset: AIM; IM |
Affiliation:
|
Department of Surgery, School of Medicine, University of Pennsylvania, Philadelphia 19104, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Dilatation, Pathologic Disease Models, Animal Heart Ventricles / pathology Mitral Valve Insufficiency / complications*, ultrasonography Myocardial Infarction / complications*, pathology* Papillary Muscles / pathology Sheep |
| Grant Support | |
ID/Acronym/Agency:
|
HL 36308/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Perivascular delivery of a nitric oxide donor inhibits neointimal hyperplasia in vein grafts implant...
Next Document: Ex vivo adenovirus-mediated gene transfer to the adult rat heart.