| Infarct size after acute myocardial infarction measured by quantitative tomographic 99mTc sestamibi imaging predicts subsequent mortality. | |
| | |
MedLine Citation:
|
PMID: 7634446 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: 99mTc sestamibi is a recently developed radioisotope that has been used to measure myocardium at risk and infarct size. The relation between these measurements and subsequent patient outcome has not yet been demonstrated. METHODS AND RESULTS: Two hundred seventy-four consecutive patients with acute myocardial infarction underwent tomographic 99mTc sestamibi imaging on arrival at the hospital (to measure myocardium at risk before reperfusion therapy) and at hospital discharge (to measure the amount of salvaged myocardium and final infarct size). Defect size on the sestamibi images was quantified using a threshold value of 60% of peak counts from the circumferential count profile curves generated for five representative slices of the left ventricle. Patients were followed after hospital discharge to evaluate the association between final infarct size and subsequent mortality. The median defect size measured was 27% of the left ventricle at presentation to the hospital (range, 0% to 77%) and was 12% of the left ventricle at hospital discharge (range, 0% to 68%). Almost one half of the patients had a final infarct size of < or = 10%. The median amount of myocardium salvaged was 9% (range, -31% to 75%). During a median duration of follow-up of 12 months, there were 10 deaths (7 cardiac and 3 noncardiac) and 1 resuscitated out-of-hospital cardiac arrest. There was a significant association between infarct size and overall mortality (chi 2 = 8.66, P = .003) and cardiac mortality (chi 2 = 11.89, P < .001). Two-year mortality was 7% for patients whose infarct size was > or = 12% versus 0% for patients whose infarct size was < 12%. There also was a significant association between myocardium at risk and cardiac mortality (chi 2 = 6.87, P = .009). There was no association between myocardium at risk and overall mortality or between amount of myocardium salvaged and either overall mortality or cardiac mortality. CONCLUSIONS: Larger infarct size measured by 99mTc sestamibi imaging after acute myocardial infarction is associated with increased mortality risk during short-term follow-up. |
| | |
Authors:
|
T D Miller; T F Christian; M R Hopfenspirger; D O Hodge; B J Gersh; R J Gibbons |
Related Documents
:
|
17382616 - Case complexity scores in congenital heart surgery: a comparative study of the aristotl... 11265096 - An abnormal dipyridamole thallium/sestamibi fails to predict long-term cardiac events i... 17070146 - Rationale and design of a randomized, double-blind, placebo-controlled trial of ivabrad... 18714616 - Heart rate and outcome in patients with cardiovascular disease undergoing major noncard... 6541866 - Improvement in left ventricular diastolic function during intravenous and oral diltiaze... 8306296 - Assessment and visualization of the curvature of the left ventricle from 3d medical ima... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Circulation Volume: 92 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1995 Aug |
Date Detail:
|
Created Date: 1995-09-12 Completed Date: 1995-09-12 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 334-41 Citation Subset: AIM; IM |
Affiliation:
|
Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Female Follow-Up Studies Humans Male Middle Aged Myocardial Infarction / mortality, physiopathology, radionuclide imaging* Prognosis Stroke Volume Technetium Tc 99m Sestamibi / diagnostic use* |
| Chemical | |
Reg. No./Substance:
|
109581-73-9/Technetium Tc 99m Sestamibi |
| Comments/Corrections | |
Comment In:
|
Circulation. 1996 Feb 1;93(3):618-9
[PMID:
8565188
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Job strain and the prevalence and outcome of coronary artery disease.
Next Document: Relation between diastolic perfusion time and coronary artery stenosis during stress-induced myocard...