| Infarct distribution in subhuman primates after acute coronary occlusion. | |
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MedLine Citation:
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PMID: 7226177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The extent of epicardial, endocardial and septal infarct was determined in 24 monkeys and five baboons 1 week after acute left anterior descending or diagonal branch coronary artery ligation. All 24 Macaca cynmologous monkeys had non-dominant left anterior descending coronary arteries. A snare ligature was placed just distal to the first diagonal branch for varying time periods (1, 2, 4, and 6 h followed by reperfusion or left in place permanently). In five baboons a chronic ligature was placed around a diagonal branch. All animals lived and were killed a week later. Histological mapping and planimetry of serial cross-sections were employed to quantify the extent and distribution of the infarct. All infarcts were transmural. The extent of epicardial infarct was significantly greater than the extent of endocardial infarct for 2 h ligations (3.5 +/- 0.87% of the left ventricle versus 2.4 +/- 0.58% of the left ventricle, P less than 0.05), the chronic left anterior descending coronary artery ligations (5.4 +/- 1.06% of the left ventricle versus 4.5 +/- 0.92% of the left ventricle, P less than 0.05 and for the chronic diagonal branch ligations (4.06 +/- 0.66% of the right ventricle + left ventricle versus 2.64 +/- 0.51+ of the right ventricle + left ventricle, P less than 0.02). It is evident, however, that the magnitude of this epicardial preponderance was not great and that, in general, the infarcts were transmural and rectangular in configuration. |
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Authors:
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B Barker; M D Rosario; V Grant; J J McNamara; G T Suehiro |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cardiovascular research Volume: 14 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 1980 Dec |
Date Detail:
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Created Date: 1981-07-23 Completed Date: 1981-07-23 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 671-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Endocardium / pathology Heart Septum / pathology Heart Ventricles / pathology Macaca fascicularis Myocardial Infarction / pathology* Myocardium / pathology* Papio |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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