Document Detail


Infarct volume after hyperacute infusion of hypertonic saline in a rat model of acute embolic stroke.
MedLine Citation:
PMID:  22886394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Hypertonic saline (HS) can treat cerebral edema arising from a number of pathologic conditions. However, physicians are reluctant to use it during the first 24 h after stroke because of experimental evidence that it increases infarct volume when administered early after reperfusion. Here, we determined the effect of HS on infarct size in an embolic clot model without planned reperfusion.
METHODS: A clot was injected into the internal carotid artery of male Wistar rats to reduce perfusion in the middle cerebral artery territory to less than 40 % of baseline, as monitored by laser-Doppler flowmetry. After 25 min, rats were randomized to receive 10 mL/kg of 7.5 % HS (50:50 chloride:acetate) or normal saline (NS) followed by a 0.5 mL/h infusion of the same solution for 22 h.
RESULTS: Infarct volume was similar between NS and HS groups (in mm(3): cortex 102 ± 65 mm(3) vs. 93 ± 49 mm(3), p = 0.72; caudoputamenal complex 15 ± 9 mm(3) vs. 21 ± 14, p = 0.22; total hemisphere 119 ± 76 mm(3) vs. 114 ± 62, p = 0.88, respectively). Percent water content was unchanged in the infarcted hemisphere (NS 81.6 ± 1.5 %; HS 80.7 ± 1.3 %, p = 0.16), whereas the HS-treated contralateral hemisphere was significantly dehydrated (NS 79.4 ± 0.8 %; HS 77.5 ± 0.8 %, p < 0.01).
CONCLUSIONS: HS reduced contralateral hemispheric water content but did not affect ipsilateral brain water content when compared to NS. Infarct volume was unaffected by HS administration at all evaluated locations.
Authors:
Alexander Papangelou; Thomas J K Toung; Allan Gottschalk; Marek A Mirski; Raymond C Koehler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Neurocritical care     Volume:  18     ISSN:  1556-0961     ISO Abbreviation:  Neurocrit Care     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-05     Completed Date:  2013-08-07     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  101156086     Medline TA:  Neurocrit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  106-14     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / drug effects*,  pathology
Brain Edema / drug therapy*,  etiology
Brain Infarction / etiology,  pathology*
Cerebral Cortex / blood supply
Disease Models, Animal
Intracranial Embolism / complications,  pathology*
Laser-Doppler Flowmetry
Male
Rats
Rats, Wistar
Saline Solution, Hypertonic / therapeutic use*
Grant Support
ID/Acronym/Agency:
NS038684/NS/NINDS NIH HHS; R01 NS038684/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Saline Solution, Hypertonic
Comments/Corrections

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