| Infants with univentricular heart have reduced heart rate and blood pressure responses to side motion and altered responses to head-up tilt. | |
| | |
MedLine Citation:
|
PMID: 15649877 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cardiovascular control was studied in infants with univentricular heart (UVH). Side motion tests and 45-s 45 degrees head-up tilt tests were performed in 11 control and 9 UVH infants at the age of 13 +/- 3.2 wk. In addition, heart rate (HR) reactions to spontaneous arousals and HR variability during slow-wave sleep (SWS) were determined. All UVH infants had been hypoxic for several weeks, and during the sleep study the mean arterial oxyhemoglobin saturation was 82 +/- 5%. Tests were done at night during SWS, confirmed by polysomnographic recording. Continuous beat-to-beat blood pressure (BP) was measured. In the side-motion tests, control infants consistently showed a transient increase in HR and BP. This response was markedly reduced in all of the UVH infants (P < 0.0001). In tilt tests, the UVH infants showed normal BP responses, but, although a sustained 2.0% decrease in HR was observed in the controls, the UVH infants presented with a sustained 2.6% mean HR increase (P = 0.005). The UVH infants also showed attenuated HR acceleration during spontaneous arousals (P = 0.01), but HR variability did not differ significantly from the controls. In conclusion, UVH infants with chronic hypoxia exhibit defective vestibulosympathetic pathways, as expressed by an absence of acute HR and BP reactivity to side motion. HR reactions to postural challenge and spontaneous arousal are also altered. Autonomic function abnormalities in these infants are suggested to be secondary to hypoxia. |
| | |
Authors:
|
Turkka Kirjavainen; Suvi Viskari; Olli Pitkänen; Eero Jokinen |
Related Documents
:
|
3605017 - Pathology of sudden infant death syndrome. 12838197 - Incidence and spectrum of neonatal lupus erythematosus: a prospective study of infants ... 6502377 - Heart rate and sleep time: their relationship with growth and adiposity in male infants. 434007 - Abnormal antepartum fetal heart rate tracings, failure to intervene, and fetal death: r... 8039377 - Categorization in early infancy and the continuity of development. 15317497 - Origins and early development of human body knowledge. |
Publication Detail:
|
Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 98 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2005 Feb |
Date Detail:
|
Created Date: 2005-01-14 Completed Date: 2005-05-24 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: 518-25 Citation Subset: IM |
Affiliation:
|
Hospital for Children and Adolescents, PO Box 281, 00029 HUS, Finland. turkka.kirjavainen@hus.fi |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anoxia
/
etiology,
physiopathology* Arousal* Blood Pressure* Chronic Disease Female Heart Rate Heart Ventricles / abnormalities*, physiopathology* Homeostasis Humans Infant, Newborn Male Movement Physical Stimulation / methods* Posture Tilt-Table Test / methods |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of eccentric exercise training on cortical bone and muscle strength in the estrogen-deficien...
Next Document: Independent metabolic costs of supporting body weight and accelerating body mass during walking.