Document Detail

Infants with late breast milk acquisition of HIV-1 generate interferon-gamma responses more rapidly than infants with early peripartum acquisition.
MedLine Citation:
PMID:  19438605     Owner:  NLM     Status:  MEDLINE    
Infants infected with HIV-1 after the first month of life have a lower viral set-point and slower disease progression than infants infected before 1 month. We investigated the kinetics of HIV-1-specific CD8(+) T lymphocyte secretion of interferon (IFN)-gamma in infants infected before 1 month of life compared with those infected between months 1 and 12 (late infection). HIV-1 infection was assessed at birth and at months 1, 3, 6, 9 and 12 and timing of infection was determined by HIV-1 gag DNA from dried blood spots and verified by plasma HIV-1 RNA levels. HIV-1 peptide-specific IFN-gamma responses were measured by enzyme-linked immunospot at months 1, 3, 6, 9 and 12. Timing of development of IFN-gamma responses was compared using the log-rank test and Kaplan-Meier survival curves. Infants infected late developed HIV-1-specific CD8(+) T cell responses 2.8 months sooner than infants infected peripartum: 2.3 versus 5.1 months after HIV-1 infection (n = 52, P = 0.04). Late-infected infants had more focused epitope recognition than early-infected infants (median 1 versus 2 peptides, P = 0.03); however, there were no differences in the strength of IFN-gamma responses. In infants infected with HIV-1 after the first month of life, emergence of HIV-1-specific CD8(+) IFN-gamma responses is coincident with the decline in viral load, nearly identical to what is observed in adults and more rapid than in early-infected infants.
B Lohman-Payne; J A Slyker; B A Richardson; C Farquhar; M Majiwa; E Maleche-Obimbo; D Mbori-Ngacha; J Overbaugh; S Rowland-Jones; G John-Stewart
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  156     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-14     Completed Date:  2009-06-17     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  511-7     Citation Subset:  IM    
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MeSH Terms
Age Factors
CD8-Positive T-Lymphocytes / immunology
Cohort Studies
HIV Infections / immunology,  transmission*,  virology
HIV-1 / immunology*,  isolation & purification
Infant, Newborn
Infectious Disease Transmission, Vertical
Interferon-gamma / biosynthesis*
Milk, Human / virology*
Pregnancy Complications, Infectious
Prenatal Exposure Delayed Effects / immunology*
Viral Load
Grant Support
D43 TW000007/TW/FIC NIH HHS; K01 AI087369/AI/NIAID NIH HHS; K01 TW06080/TW/FIC NIH HHS; K24 HD054314/HD/NICHD NIH HHS; MC_U137884180//Medical Research Council; P30 AI027757/AI/NIAID NIH HHS; R01 HD023412/HD/NICHD NIH HHS; R01 HD23412-14/HD/NICHD NIH HHS; //Medical Research Council
Reg. No./Substance:

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