| Infants with late breast milk acquisition of HIV-1 generate interferon-gamma responses more rapidly than infants with early peripartum acquisition. | |
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MedLine Citation:
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PMID: 19438605 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infants infected with HIV-1 after the first month of life have a lower viral set-point and slower disease progression than infants infected before 1 month. We investigated the kinetics of HIV-1-specific CD8(+) T lymphocyte secretion of interferon (IFN)-gamma in infants infected before 1 month of life compared with those infected between months 1 and 12 (late infection). HIV-1 infection was assessed at birth and at months 1, 3, 6, 9 and 12 and timing of infection was determined by HIV-1 gag DNA from dried blood spots and verified by plasma HIV-1 RNA levels. HIV-1 peptide-specific IFN-gamma responses were measured by enzyme-linked immunospot at months 1, 3, 6, 9 and 12. Timing of development of IFN-gamma responses was compared using the log-rank test and Kaplan-Meier survival curves. Infants infected late developed HIV-1-specific CD8(+) T cell responses 2.8 months sooner than infants infected peripartum: 2.3 versus 5.1 months after HIV-1 infection (n = 52, P = 0.04). Late-infected infants had more focused epitope recognition than early-infected infants (median 1 versus 2 peptides, P = 0.03); however, there were no differences in the strength of IFN-gamma responses. In infants infected with HIV-1 after the first month of life, emergence of HIV-1-specific CD8(+) IFN-gamma responses is coincident with the decline in viral load, nearly identical to what is observed in adults and more rapid than in early-infected infants. |
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Authors:
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B Lohman-Payne; J A Slyker; B A Richardson; C Farquhar; M Majiwa; E Maleche-Obimbo; D Mbori-Ngacha; J Overbaugh; S Rowland-Jones; G John-Stewart |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 156 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-14 Completed Date: 2009-06-17 Revised Date: 2013-02-08 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 511-7 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, University of Nairobi, Nairobi, Kenya. blpayne@iconnect.co.ke |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors CD8-Positive T-Lymphocytes / immunology Cohort Studies Female HIV Infections / immunology, transmission*, virology HIV-1 / immunology*, isolation & purification Humans Infant Infant, Newborn Infectious Disease Transmission, Vertical Interferon-gamma / biosynthesis* Milk, Human / virology* Pregnancy Pregnancy Complications, Infectious Prenatal Exposure Delayed Effects / immunology* Viral Load |
| Grant Support | |
ID/Acronym/Agency:
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D43 TW000007/TW/FIC NIH HHS; K01 AI087369/AI/NIAID NIH HHS; K01 TW06080/TW/FIC NIH HHS; K24 HD054314/HD/NICHD NIH HHS; K24 HD054314-03/HD/NICHD NIH HHS; P30 AI027757/AI/NIAID NIH HHS; R01 HD023412/HD/NICHD NIH HHS; R01 HD023412-15/HD/NICHD NIH HHS; R01 HD23412-14/HD/NICHD NIH HHS; //Medical Research Council |
| Chemical | |
Reg. No./Substance:
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82115-62-6/Interferon-gamma |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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