Document Detail

Infants presenting with recurrent infections and low immunoglobulins: characteristics and analysis of normalization.
MedLine Citation:
PMID:  16418798     Owner:  NLM     Status:  MEDLINE    
To better characterize infants presenting with diminished immunoglobulin levels and intact antibody formation, we present 49 such infants, correlating presenting characteristics with history and time to immunoglobulin normalization. Term infants with the following characteristics were included: 1) one or more immunoglobulin classes > 2SD below mean, 2) protective antibody titer to tetanus and diphtheria, 3) intact cellular immunity, 4) no features of other syndromes. The children were 69.4% male and had recurrent otitis media (77.6%), wheezing (61.2%), and atopy (26.5%). Diminished IgA (95.9%) was most common, but 65.3% had multiple isotypes diminished. During follow-up, 25/49 (51%) normalized immunoglobulins, of whom 80% were male; only 48% normalized in infancy. Female immunoglobulin normalization was significantly delayed (p < .001). No deaths or serious infections occurred. This phenotype is predominantly seen in male infants with otitis media and wheezing. Female infants have significantly delayed immunoglobulin normalization. Transient hypogammaglobulinemia of infancy can be diagnosed only retrospectively.
M A Whelan; W H Hwan; J Beausoleil; W W Hauck; S J McGeady
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical immunology     Volume:  26     ISSN:  0271-9142     ISO Abbreviation:  J. Clin. Immunol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-18     Completed Date:  2006-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102137     Medline TA:  J Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7-11     Citation Subset:  IM    
Division of Allergy & Immunology, Thomas Jefferson University, Philadelphia, PA, USA.
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MeSH Terms
Agammaglobulinemia / complications,  immunology*,  therapy
Antibody Formation*
Child, Preschool
Disease Progression
Follow-Up Studies
Immunoglobulin A / blood
Immunoglobulin G / blood
Immunoglobulin M / blood
Immunologic Deficiency Syndromes / diagnosis*
Infant, Newborn
Infection / complications*
Prospective Studies
Recurrence / prevention & control
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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