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MedLine Citation:
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PMID: 9263182 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Insulin-Dependent Diabetes (IDD) results from an autoimmune destruction of the insulin secreting pancreatic beta cells. The immunological mechanisms underlying the development of IDD as well as the role of environmental agents (e.g., diet, viruses, stress) in the pathogenesis of the disease are the subject of considerable research efforts. Significant attention has recently been directed to a hypothesis that consumption of cows' milk in infancy may trigger the autoimmune process underlying IDD. Early evidence supporting this "cows' milk hypothesis" included case-control studies surveying infant nutrition practices (i.e., breast feeding versus consumption of infant formula) and the subsequent development of IDD. However, intense media interest surrounding a report indicating anti-bovine serum albumin (BSA) immunity as the cause of IDD has lead to heightened public awareness of the issue, and, together with the epidemiological data, prompted The American Academy of Pediatrics to modify its guidelines for infant feeding practices. However, less public and scientific attention has been given toward the observations that many of these case-control studies were retrospective in design and subject to recall bias, narrow in scope in terms of collecting dietary information, and that similar results have not been duplicated in other more recent (and better designed) investigations. Furthermore, the immunological report implicating anti-BSA immunity with the disease has become controversial due to difficulties in conforming the findings, and experiments in animal models closely resembling human IDD have not uniformly supported a role for anti-BSA immunity in the pathogenesis of IDD. Given the significant morbidity and mortality associated with IDD, an improved understanding of the cause of this disorder as well as identifying possible methods for its prevention are essential. However, without additional supporting information, modification of the cows' milk/BSA composition of diets in order to avoid the disease may be premature. Further studies are needed to clearly establish a role for diet in the pathogenesis of IDD. |
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Authors:
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M A Atkinson; T M Ellis |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of the American College of Nutrition Volume: 16 ISSN: 0731-5724 ISO Abbreviation: J Am Coll Nutr Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-09-25 Completed Date: 1997-09-25 Revised Date: 2008-06-23 |
Medline Journal Info:
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Nlm Unique ID: 8215879 Medline TA: J Am Coll Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 334-40 Citation Subset: IM |
Affiliation:
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Department of Pathology, College of Medicine, University of Florida, Gainesville, Florida 32610, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cattle Diabetes Mellitus, Type 1 / immunology* Disease Models, Animal Humans Infant Infant Food* Milk / immunology* Serum Albumin, Bovine / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Serum Albumin, Bovine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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