Document Detail

Infants at risk for psychopathology: offspring of schizophrenic parents.
MedLine Citation:
PMID:  6354633     Owner:  NLM     Status:  MEDLINE    
The results of research on infants at high risk for schizophrenia (offspring of schizophrenic parents) are reviewed. The findings indicate that high-risk infants are not exposed to greater exogenous stress during the prenatal and perinatal periods, although subsequent caregiving provided by disturbed mothers may be nonoptimal. Several findings point to the existence of a constitutionally vulnerable subgroup of high-risk infants. Fetal and neonatal deaths, unrelated to obstetrical complications, may be more common among high-risk offspring, and neuromotor abnormalities are apparent in a subgroup of high-risk subjects across the life span. Moreover, there is evidence to suggest that offspring of schizophrenics are uniquely susceptible to obstetrical complications when they occur: Neuromotor deficits and other developmental deviations show a greater relationship with obstetrical complications among high-risk infants than controls. Taken together, the results lend support to the validity of interactional models of the etiology of schizophrenia and suggest that preventive intervention may be a realistic goal.
E Walker; E Emory
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Child development     Volume:  54     ISSN:  0009-3920     ISO Abbreviation:  Child Dev     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-12-20     Completed Date:  1983-12-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372725     Medline TA:  Child Dev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1269-85     Citation Subset:  IM    
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MeSH Terms
Birth Weight
Fetal Death / etiology
Infant Mortality
Infant, Newborn
Mother-Child Relations
Obstetric Labor Complications
Parents / psychology*
Pregnancy Complications
Psychomotor Performance
Schizophrenia / etiology,  genetics*
Schizophrenic Psychology
Social Class
Stress, Physiological / complications

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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