Document Detail

Infants of human immunodeficiency virus type 1-infected women in rural south India: feeding patterns and risk of mother-to-child transmission.
MedLine Citation:
PMID:  19910839     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We assessed the infant feeding choices of HIV-1-infected women in rural Tamil Nadu, India, and risk factors for mother-to-child transmission of HIV-1. METHODS: The study population comprised live born infants of HIV-1-infected women from the antenatal clinics of 2 public hospitals in rural Tamil Nadu, India who were enrolled in a prospective cohort study. All women enrolled in the cohort were offered antiretroviral prophylaxis and infant feeding counseling based on WHO/UNAIDS/UNICEF training materials. Infant study visits were scheduled at birth (within the first 24 hours of life), at 1 week, 1 month, and 2 months after birth, and then every 2 months between 4 and 12 months of age. RESULTS: One-third of women did not breast-feed their infants. Of those who initiated breast-feeding, the median duration of breast-feeding was approximately 3 months. Among those infants who initiated breast-feeding, the proportion exclusively breast-feeding declined from approximately 70% during the first week of life to 0% by the 8 month visit. The observed rate of mother-to-child transmission of HIV-1 in the entire cohort was 6.5% (95% CI: 1.4%-17.9%). The observed HIV-1 incidence among breast-fed infants was 0% (95% CI: 0%-8.9%). CONCLUSION: The overall transmission rate was relatively low, suggesting effectiveness of antiretroviral transmission prophylaxis. The infant feeding choices made may reflect knowledge gained through the educational program and infant feeding counseling provided. Ensuring HIV-1-infected women receive appropriate HIV-1 treatment (for those who meet criteria for treatment) and access to known efficacious interventions to prevent mother-to-child transmission of HIV-1, are essential.
Jennifer S Read; N M Samuel; Parameshwari Srijayanth; Shoba Dharmarajan; Hannah M Van Hook; Mini Jacob; Viju Junankar; James Bethel; Eunice Yu; Sonia K Stoszek;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  29     ISSN:  1532-0987     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-29     Completed Date:  2010-02-26     Revised Date:  2010-04-29    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14-7     Citation Subset:  IM    
Pediatric, Adolescent, and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health Executive Building, Room 4B11C, 6100 Executive Boulevard MSC 7510, Bethesda, MD 20892-7510.
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MeSH Terms
Anti-HIV Agents / therapeutic use
Breast Feeding / adverse effects*
Cohort Studies
Feeding Behavior*
HIV Infections / drug therapy,  epidemiology*,  transmission*
HIV-1 / isolation & purification*
India / epidemiology
Infant, Newborn
Infectious Disease Transmission, Vertical*
Prospective Studies
Risk Assessment*
Rural Population
Grant Support
N01-3-3345//PHS HHS
Reg. No./Substance:
0/Anti-HIV Agents
R Elango / ; S Shobhana / ; J Vijayakumari / ; G Jaganathan / ; H Rathinam / ; M Devi / ; R Ramachandran / ; E Thangaraj / ; M Annadurai / ; R Suganya / ; S Raju / ; K Senthilkumar / ; S Sudha / ; M Ekambaram / ; A Jennit / ; A Andrew / ; V Venila / ; S Vijayalakshmi / ; S Subramaniam / ; S Kavitha / ; V Thilagavathy / ; T Anitha / ; S Kulandaivelu / ; S Mahalingam / ; T Sivarani / ; E Radha / ; R Rajkumar / ; A Anandhan / ; Y Li / ; M Manoharan / ; D Collins / ; A Shahid /

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