| Infantile spasms: a pathophysiological hypothesis | |
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MedLine Citation:
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PMID: 9422224 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Clinical and electroencephalogram (EEG) observations permit a hypothesis for the pathophysiology of infantile spasms. The triggering area(s) for spasms is probably cortical. Diffuse hyperexcitability of the immature cortex and/or diffusion of the epileptic process from a focal abnormality would allow development of hypsarrhythmia. Cortical maturation from posterior to anterior might account for the location of causative focal abnormalities. In cryptogenic West syndrome, the predominant pathophysiologic process may be diffuse cortical hyperexcitability, explaining the severe developmental deterioration at the onset of spasms. In symptomatic West syndrome with focal pathology, the initial deterioration is often less striking, suggesting that the predominant effect is diffusion of the epileptic process. The pattern of eventual cognitive deficits follows a similar pattern. |
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Authors:
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Dulac; Chiron; Robain; Plouin; Jambaque; Pinard |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Seminars in pediatric neurology Volume: 1 ISSN: 1558-0776 ISO Abbreviation: Semin Pediatr Neurol Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1998-01-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9441351 Medline TA: Semin Pediatr Neurol Country: UNITED STATES |
Other Details:
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Languages: Eng Pagination: 83-9 Citation Subset: - |
Affiliation:
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Inserm U29, Paris, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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