| Infantile spasms in an infant with cytomegalovirus infection treated with ganciclovir. | |
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MedLine Citation:
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PMID: 15032385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 3-month-old male infant with cytomegalovirus infection and intractable partial seizures was treated with ganciclovir for 6 weeks. The drug was well tolerated, and virus shedding in the cerebrospinal fluid and urine was eliminated, although infantile spasms at the age of 6 months appeared. At the age of 12 months, intractable seizures persisted, and the psychomotor development of the infant was markedly delayed. To our knowledge, no previous similar case has been reported. These findings suggest that treatment with ganciclovir of infants with cytomegalovirus infection results only in cessation of virus shedding in the cerebrospinal fluid and urine without having a preventive effect on the future appearance of infantile spasms. This may be due to the irreversibility of previous brain damage from the cytomegalovirus infection and the virostatic nature of the drug. |
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Authors:
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Konstantinos Voudris; Eleni A Vagiakou; Sotiria Mastroyianni; Yboni Dimitriou; Angeliki Skardoutsou |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of child neurology Volume: 19 ISSN: 0883-0738 ISO Abbreviation: J. Child Neurol. Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-03-22 Completed Date: 2004-08-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: Canada |
Other Details:
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Languages: eng Pagination: 50-3 Citation Subset: IM |
Affiliation:
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Department of Neurology, "P & A Kyriakou" Children's Hospital, Athens, Greece. kvoudris@otenet.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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therapeutic use Antiviral Agents / therapeutic use* Atrophy Brain / pathology Brain Damage, Chronic / diagnosis Cytomegalovirus Infections / congenital, diagnosis, drug therapy* Developmental Disabilities / diagnosis Diagnosis, Differential Diagnostic Imaging Disease Progression Drug Therapy, Combination Electroencephalography / drug effects Encephalitis, Viral / congenital, diagnosis, drug therapy* Epilepsies, Partial / diagnosis, drug therapy* Follow-Up Studies Ganciclovir / therapeutic use* Humans Infant Male Spasms, Infantile / diagnosis, drug therapy* Virus Shedding / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Antiviral Agents; 82410-32-0/Ganciclovir |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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