Document Detail


Infantile spasms in an infant with cytomegalovirus infection treated with ganciclovir.
MedLine Citation:
PMID:  15032385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 3-month-old male infant with cytomegalovirus infection and intractable partial seizures was treated with ganciclovir for 6 weeks. The drug was well tolerated, and virus shedding in the cerebrospinal fluid and urine was eliminated, although infantile spasms at the age of 6 months appeared. At the age of 12 months, intractable seizures persisted, and the psychomotor development of the infant was markedly delayed. To our knowledge, no previous similar case has been reported. These findings suggest that treatment with ganciclovir of infants with cytomegalovirus infection results only in cessation of virus shedding in the cerebrospinal fluid and urine without having a preventive effect on the future appearance of infantile spasms. This may be due to the irreversibility of previous brain damage from the cytomegalovirus infection and the virostatic nature of the drug.
Authors:
Konstantinos Voudris; Eleni A Vagiakou; Sotiria Mastroyianni; Yboni Dimitriou; Angeliki Skardoutsou
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of child neurology     Volume:  19     ISSN:  0883-0738     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-03-22     Completed Date:  2004-08-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  50-3     Citation Subset:  IM    
Affiliation:
Department of Neurology, "P & A Kyriakou" Children's Hospital, Athens, Greece. kvoudris@otenet.gr
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MeSH Terms
Descriptor/Qualifier:
Anticonvulsants / therapeutic use
Antiviral Agents / therapeutic use*
Atrophy
Brain / pathology
Brain Damage, Chronic / diagnosis
Cytomegalovirus Infections / congenital,  diagnosis,  drug therapy*
Developmental Disabilities / diagnosis
Diagnosis, Differential
Diagnostic Imaging
Disease Progression
Drug Therapy, Combination
Electroencephalography / drug effects
Encephalitis, Viral / congenital,  diagnosis,  drug therapy*
Epilepsies, Partial / diagnosis,  drug therapy*
Follow-Up Studies
Ganciclovir / therapeutic use*
Humans
Infant
Male
Spasms, Infantile / diagnosis,  drug therapy*
Virus Shedding / drug effects
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Antiviral Agents; 82410-32-0/Ganciclovir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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