Document Detail


Infantile spasm: the effect of corticotropin (ACTH) on the free amino acid profile in cerebrospinal fluid.
MedLine Citation:
PMID:  10082248     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Increased excitatory amino acid neurotransmission has been implicated in the pathogenesis of infantile spasm. In this study we studied the profile of free amino acids in cerebrospinal fluid (CSF) from 16 patients with infantile spasm before corticotropin (ACTH) treatment. After 10 weeks ACTH therapy the profile of amino acids in CSF was studied once more in eight of the patients. Eleven patients were in the symptomatic group, and five in the cryptogenic group. Increased aspartate levels were measured in CSF following ACTH therapy (P<0.05). It was concluded that aspartate might have an important role in hypothalamic-hypophyseal axis in patients with infantile spasm.
Authors:
H Tekgül; S Tütüncüoglu; M Coker; C Coker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain & development     Volume:  21     ISSN:  0387-7604     ISO Abbreviation:  Brain Dev.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-05-05     Completed Date:  1999-05-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909235     Medline TA:  Brain Dev     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  20-3     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / therapeutic use*
Amino Acids / cerebrospinal fluid*
Aspartic Acid / cerebrospinal fluid
Female
Follow-Up Studies
Humans
Infant
Male
Spasms, Infantile / cerebrospinal fluid*,  drug therapy*
Chemical
Reg. No./Substance:
0/Amino Acids; 56-84-8/Aspartic Acid; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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