Document Detail

Infantile myofibroma in a prematurely born twin: a case report.
MedLine Citation:
PMID:  12869160     Owner:  NLM     Status:  MEDLINE    
Infantile myofibromatosis is a rare benign tumor of infancy and childhood that occurs in solitary, multiple, and generalized forms with similar histology but different clinicopathologic and prognostic implications. Even solitary tumors need follow-up, as the type of presentation will be determined over time. It is necessary to differentiate this entity from other more aggressive tumors, especially rhabdomyosarcoma, which is treated by chemotherapy prior to excision. We describe a prematurely born twin girl who had at birth a solitary tumor of the cervicoscapular region, involving the dermis and subcutis. A fine-needle aspiration biopsy (FNAB) specimen obtained soon after her birth suggested a diagnosis of benign neoplasm. The tumor was excised 1 month later, at which time it was significantly enlarged, ulcerated, and also exhibited worrisome histologic features including mitoses and infiltrative growth. It had the characteristic histologic pattern of infantile myofibromatosis, and myofibroblastic features of tumor cells were confirmed immunohistochemically and ultrastructurally. During the follow-up period of 39 months, there was no sign of recurrence or new tumors.
Vesna Jurcić; Tanja Perković; Ziva Pohar-Marinsek; Asta Hvala; Inka Lazar
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric dermatology     Volume:  20     ISSN:  0736-8046     ISO Abbreviation:  Pediatr Dermatol     Publication Date:    2003 Jul-Aug
Date Detail:
Created Date:  2003-07-18     Completed Date:  2003-12-18     Revised Date:  2009-03-03    
Medline Journal Info:
Nlm Unique ID:  8406799     Medline TA:  Pediatr Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  345-9     Citation Subset:  IM    
Institute of Pathology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia.
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MeSH Terms
Diseases in Twins*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / pathology*,  surgery
Leiomyoma / congenital*,  pathology*,  surgery
Skin Neoplasms / congenital*,  pathology*,  surgery
Twins, Dizygotic

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