Document Detail

Infantile hemangioendothelioma with a highly elevated serum alpha-fetoprotein level.
MedLine Citation:
PMID:  9638427     Owner:  NLM     Status:  MEDLINE    
Infantile hemangioendothelioma is the most common vascular tumor in infancy. A three-month-old infant was admitted to the hospital for hepatomegaly. Abdominal ultrasonography, a CT-scan, and MRI studies demonstrated bilateral diffuse hepatic nodules, which were characteristic of hepatic hemangioendothelioma. A highly elevated alpha-fetoprotein (AFP) level misled us to an impression of hepatoblastoma, but the pathology report through an open biopsy disclosed a liver hemangioendothelioma. The patient responded to methylprednisolone therapy. A follow-up sonogram revealed regression of the hepatic masses. This case emphasizes that an elevated AFP level of up to 400 ng/ml is normally found in some neonates until two months of age. Careful interpretation of this value is very important, especially when it is associated with a hepatic tumor. Herein, we present a case of infantile hemangioendothelioma in a three-month-old boy with a highly elevated serum AFP.
S J Han; C C Tsai; H M Tsai; Y J Chen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  45     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    1998 Mar-Apr
Date Detail:
Created Date:  1998-09-03     Completed Date:  1998-09-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  459-61     Citation Subset:  IM    
Department of Radiology, Tainan Municipal Hospital, Taiwan.
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MeSH Terms
Diagnostic Imaging
Glucocorticoids / therapeutic use
Hemangioendothelioma / blood,  diagnosis*,  drug therapy
Liver Neoplasms / blood,  diagnosis*,  drug therapy
Methylprednisolone / therapeutic use
Tumor Markers, Biological / blood*
alpha-Fetoproteins / analysis*
Reg. No./Substance:
0/Glucocorticoids; 0/Tumor Markers, Biological; 0/alpha-Fetoproteins; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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