Document Detail

Infantile granular parakeratosis: recognition of two clinical patterns.
MedLine Citation:
PMID:  15097939     Owner:  NLM     Status:  MEDLINE    
Granular parakeratosis is an acquired, idiopathic disorder of keratinization typified by retention hyperkeratosis. It usually occurs in women at intertriginous sites. There have been only 2 reports of infants with granular parakeratosis to our knowledge. We describe 3 additional infants with granular parakeratosis. We demonstrate that infantile granular parakeratosis exhibits 2 clinical patterns: bilateral linear plaques in the inguinal folds; and erythematous geometric plaques underlying pressure points from the diaper. A thick, flakelike scale is present in both forms and is characteristic. Diaper wearing appears to play an important role in the genesis of infantile granular parakeratosis but the mechanisms are unclear. Therapeutic responsiveness to topical agents is ambiguous, however, spontaneous clearance after months to 1 year appears to be the rule.
Mary Wu Chang; Julie M Kaufmann; Seth J Orlow; David E Cohen; Narciss Mobini; Hideko Kamino
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  50     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-20     Completed Date:  2004-06-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S93-6     Citation Subset:  IM    
The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA.
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MeSH Terms
Diagnosis, Differential
Diaper Rash / diagnosis
Diapers, Infant
Parakeratosis / diagnosis*,  etiology,  pathology
Skin / pathology*

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