Document Detail

Infantile eczema at one month of age is associated with cord blood eosinophilia and subsequent development of atopic dermatitis and wheezing illness until two years of age.
MedLine Citation:
PMID:  15947488     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Physiological and pathological skin eruptions are commonly encountered in neonates in our clinical practice. However, the types of skin eruptions that are associated with the subsequent development of atopic dermatitis and the mechanisms of these associations remain uncertain. METHODS: A total of 105 newborn babies with normal delivery were enrolled in this prospective cohort study. The cord blood eosinophil count was measured and the neonates were examined at 1 month of age and followed until 8 years of age. RESULTS: At 1 month of age, infantile eczema, seborrheic dermatitis, intertrigo and diaper dermatitis were diagnosed in a total of 29, 7, 14 and 24 neonates, respectively. No association was found among the prevalences of these eruptions. Neonates with infantile eczema had a significantly higher number and ratio of eosinophils in the cord blood (eosinophil count: 670.8 +/- 67.8 vs. 349.0 +/- 30.3/microl, p < 0.0001; eosinophil ratio: 5.12 +/- 0.53 vs. 2.61 +/- 0.22%, p < 0.0001, for the presence and the absence of infantile eczema, respectively). In contrast, no such tendency was found for any other skin eruptions. In neonates with infantile eczema at 1 month of age, the diagnosis of atopic dermatitis had been made significantly earlier and the prevalence of wheezing illness was significantly higher than in those without infantile eczema until 2 years of age. CONCLUSION: Infantile eczema, but not other skin eruptions, precedes the development of atopic dermatitis and wheezing illness during early infancy, presumably because of the activation of eosinophils before birth.
Kenji Matsumoto; Yasuhiro Shimanouchi; Keiichi Kawakubo; Naobumi Oishi; Hiroshi Wakiguchi; Kyoko Futamura; Hirohisa Saito
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-06-02
Journal Detail:
Title:  International archives of allergy and immunology     Volume:  137 Suppl 1     ISSN:  1018-2438     ISO Abbreviation:  Int. Arch. Allergy Immunol.     Publication Date:  2005  
Date Detail:
Created Date:  2005-06-10     Completed Date:  2005-07-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9211652     Medline TA:  Int Arch Allergy Immunol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  69-76     Citation Subset:  IM    
Copyright Information:
Copyright 2005 S. Karger AG, Basel.
Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
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MeSH Terms
Cohort Studies
Dermatitis, Atopic / blood*,  epidemiology*,  immunology
Eosinophilia / blood*,  immunology
Fetal Blood / cytology*
Follow-Up Studies
Infant, Newborn
Leukocyte Count
Prospective Studies
Respiratory Sounds / etiology,  immunology

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