Document Detail


Infant with in utero ketamine exposure: quantitative measurement of residual dosage in hair.
MedLine Citation:
PMID:  20951358     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The drug ketamine is frequently abused for recreational use in Asia, but few studies in humans have focused on the effects of ketamine exposure during pregnancy on the health of neonates. Here, we report a neonate whose mother was suspected of ketamine abuse during pregnancy. The case was confirmed by testing hair samples of the neonate. METHODS: Hair samples of the neonate were taken on the first day of referral. Levels of common drugs of abuse in Asia were measured in the hair sample by gas chromatography-mass spectrometry using our previously reported method with modifications. This method was developed and validated to simultaneously quantify levels of amphetamine, ketamine and opiate in human hair. RESULTS: The neonate was a female baby, born full term, with a low birth weight of 2250 g. Very high levels of ketamine were detected in the neonate's hair, even though the mother stated that she had stopped abusing ketamine during the early stage of pregnancy. The neonate suffered from general hypotonia; moderate cerebral dysfunction was found by electroencephalography. Fortunately, her hypotonia improved gradually within 21 days. CONCLUSION: This is the first report of ketamine exposure during late pregnancy detected by hair testing. We noted several clinical features in this case, including the infant being small for gestational age, intrauterine growth retardation, remarkable hypotonia, and poor reflex responses. Although the mother denied the use of ketamine during the late stage of her pregnancy, significant amount of ketamine and norketamine was still found in hair samples (only 2 cm long and 25 mg) from the infant.
Authors:
Pen-Hua Su; Yan-Zin Chang; Jia-Yuh Chen
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatrics and neonatology     Volume:  51     ISSN:  1875-9572     ISO Abbreviation:  Pediatr Neonatol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-18     Completed Date:  2010-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101484755     Medline TA:  Pediatr Neonatol     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  279-84     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Taiwan Pediatric Association. Published by Elsevier B.V. All rights reserved.
Affiliation:
Division of Genetics, Department of Pediatrics, Chung Shan Medical University Hospital, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Fetus / drug effects*
Gas Chromatography-Mass Spectrometry
Hair / chemistry*
Humans
Infant, Newborn
Ketamine / analysis*
Pregnancy
Substance-Related Disorders / diagnosis*
Chemical
Reg. No./Substance:
6740-88-1/Ketamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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