Document Detail

Infant survival is improved by oral iodine supplementation.
MedLine Citation:
PMID:  9109607     Owner:  NLM     Status:  MEDLINE    
Although reports suggest that infant mortality is increased during iodine deficiency, the effect of iodine supplementation on infant mortality is unknown. A double-masked, randomized, placebo-controlled, clinical trial of oral iodized oil was conducted in Subang, West Java, Indonesia to evaluate the effect of iodine supplementation on infant mortality. Infants were allocated to receive placebo or oral iodized oil (100 mg) at about 6 wk of age and were followed to 6 mo of age. Six hundred seventeen infants were enrolled in the study. Infant survival was apparently improved, as indicated by a 72% reduction in the risk of death during the first 2 mo of follow-up (P < 0.05) and a delay in the mean time to death among infants who died in the iodized oil group compared with infants who died in the placebo group (48 days vs. 17.5 d, P = 0.06). Other infant characteristics associated with reduced risk of death included weight-for-age at base line, consumption of solid foods, female gender and recent history of maternal iodine supplementation. Oral iodized oil supplementation had a stronger effect on the mortality of males compared with females. This study suggests that oral iodized oil supplementation of infants may reduce infant mortality in populations at risk for iodine deficiency.
C Cobra; Muhilal; K Rusmil; D Rustama; Djatnika; S S Suwardi; D Permaesih; Muherdiyantiningsih; S Martuti; R D Semba
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  127     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-05-15     Completed Date:  1997-05-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  574-8     Citation Subset:  IM    
Department of International Health, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA.
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MeSH Terms
Administration, Oral
Body Weight
Deficiency Diseases / therapy
Double-Blind Method
Infant Mortality*
Iodine / deficiency*
Iodized Oil / therapeutic use*
Sex Factors
Survival Analysis
Reg. No./Substance:
7553-56-2/Iodine; 8001-40-9/Iodized Oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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