| Infant sex, obstetric risk factors, and 2-year neurodevelopmental outcome among preterm infants. | |
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MedLine Citation:
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PMID: 19416336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To evaluate the effect of the interaction between fetal sex and obstetric variables on the risk of neurodevelopmental impairment among preterm infants. METHOD: A cohort study of 394 male and 360 female surviving infants born at 24 to 33 completed weeks of gestational age. Neurological examination and cognitive assessment of the infants (Bayley Scales of Infant Development) were performed at 2 years corrected age. RESULTS: Mean gestational age was 30.4 weeks (SD 2.4). Rates of mild and moderate-to-severe neurodevelopmental impairment were 14.6% (110/754) and 7% (53/754) respectively. In logistic analysis, male sex was associated with an increased risk of neurodevelopmental impairment (odds ratio 1.8, 95% confidence interval 1.21-2.68) compared with females. The excess risk of neurodevelopmental impairment associated with male sex was higher among preeclamptic than normotensive pregnancies (p for interaction=0.004), among infants who were either small for gestational age or delivered to a mother with preeclampsia (p for interaction=0.001) and in iatrogenic as opposed to spontaneous preterm birth or preterm premature rupture of membranes (p for interaction=0.035). INTERPRETATION: The excess risk of neurodevelopmental impairment associated with male sex among preterm infants is modulated by obstetric risk factors. |
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Authors:
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Arsenio Spinillo; Laura Montanari; Barbara Gardella; Marianna Roccio; Mauro Stronati; Elisa Fazzi |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2009-03-11 |
Journal Detail:
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Title: Developmental medicine and child neurology Volume: 51 ISSN: 1469-8749 ISO Abbreviation: Dev Med Child Neurol Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-22 Completed Date: 2009-07-15 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0006761 Medline TA: Dev Med Child Neurol Country: England |
Other Details:
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Languages: eng Pagination: 518-25 Citation Subset: IM |
Affiliation:
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University of Pavia, Department of Obstetrics and Gynecology, IRCCS Fondazione Policlinico San Matteo, P le Golgi, 25, Pavia 27100, Italy. spinillo@smatteo.pv.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Child Development Child, Preschool Cohort Studies Delivery, Obstetric / adverse effects, classification* Developmental Disabilities / epidemiology*, etiology Disease Susceptibility Female Follow-Up Studies Gestational Age Humans Infant Infant, Newborn Infant, Premature* Italy / epidemiology Logistic Models Male Nervous System Diseases / epidemiology*, etiology Pregnancy Premature Birth* Risk Factors Sex Factors |
| Comments/Corrections | |
Comment In:
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Dev Med Child Neurol. 2009 Jul;51(7):496-7
[PMID:
19538421
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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