Document Detail

Infant sex, obstetric risk factors, and 2-year neurodevelopmental outcome among preterm infants.
MedLine Citation:
PMID:  19416336     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate the effect of the interaction between fetal sex and obstetric variables on the risk of neurodevelopmental impairment among preterm infants. METHOD: A cohort study of 394 male and 360 female surviving infants born at 24 to 33 completed weeks of gestational age. Neurological examination and cognitive assessment of the infants (Bayley Scales of Infant Development) were performed at 2 years corrected age. RESULTS: Mean gestational age was 30.4 weeks (SD 2.4). Rates of mild and moderate-to-severe neurodevelopmental impairment were 14.6% (110/754) and 7% (53/754) respectively. In logistic analysis, male sex was associated with an increased risk of neurodevelopmental impairment (odds ratio 1.8, 95% confidence interval 1.21-2.68) compared with females. The excess risk of neurodevelopmental impairment associated with male sex was higher among preeclamptic than normotensive pregnancies (p for interaction=0.004), among infants who were either small for gestational age or delivered to a mother with preeclampsia (p for interaction=0.001) and in iatrogenic as opposed to spontaneous preterm birth or preterm premature rupture of membranes (p for interaction=0.035). INTERPRETATION: The excess risk of neurodevelopmental impairment associated with male sex among preterm infants is modulated by obstetric risk factors.
Arsenio Spinillo; Laura Montanari; Barbara Gardella; Marianna Roccio; Mauro Stronati; Elisa Fazzi
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-03-11
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  51     ISSN:  1469-8749     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-22     Completed Date:  2009-07-15     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  518-25     Citation Subset:  IM    
University of Pavia, Department of Obstetrics and Gynecology, IRCCS Fondazione Policlinico San Matteo, P le Golgi, 25, Pavia 27100, Italy.
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MeSH Terms
Child Development
Child, Preschool
Cohort Studies
Delivery, Obstetric / adverse effects,  classification*
Developmental Disabilities / epidemiology*,  etiology
Disease Susceptibility
Follow-Up Studies
Gestational Age
Infant, Newborn
Infant, Premature*
Italy / epidemiology
Logistic Models
Nervous System Diseases / epidemiology*,  etiology
Premature Birth*
Risk Factors
Sex Factors
Comment In:
Dev Med Child Neurol. 2009 Jul;51(7):496-7   [PMID:  19538421 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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