Document Detail

Infant pertussis deaths and the management of cardiovascular compromise.
MedLine Citation:
PMID:  15009556     Owner:  NLM     Status:  MEDLINE    
Infants infected with Bordetella pertussis in the first few weeks of life are at risk of death from 'overwhelming cardiovascular compromise despite intensive care support'. The mechanisms of this severe disease are not completely understood. Three case histories, including that of one infant who survived, are presented. Two of the patients died despite intensive therapy with pressors and, in one child, milrinone. The third child survived following treatment with nitric oxide and sildenafil. Hence, sildenafil in combination with nitric oxide shows promise as a therapy for the haemodynamic consequences of pertussis toxaemia and this should prompt clinical trials for their efficacy for this condition.
J A McEniery; R G Delbridge; D M Reith
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  40     ISSN:  1034-4810     ISO Abbreviation:  J Paediatr Child Health     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-10     Completed Date:  2004-09-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  230-2     Citation Subset:  IM    
Intensive Care, Royal Children's Hospital, Brisbane, Queensland, Australia.
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MeSH Terms
Bordetella pertussis / isolation & purification
Cardiovascular Diseases / drug therapy*,  etiology*
Drug Therapy, Combination
Infant, Newborn
Nitric Oxide / therapeutic use*
Piperazines / therapeutic use*
Vasodilator Agents / therapeutic use*
Whooping Cough / complications*,  microbiology,  mortality*
Reg. No./Substance:
0/Piperazines; 0/Purines; 0/Sulfones; 0/Vasodilator Agents; 10102-43-9/Nitric Oxide; 139755-83-2/sildenafil

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