Document Detail

Infant and perinatal pulmonary hypoplasia frequently associated with brainstem hypodevelopment.
MedLine Citation:
PMID:  19288128     Owner:  NLM     Status:  MEDLINE    
Recent anatomo-pathological studies have revealed a frequent associated hypoplasia of both arcuate nucleus and lungs in stillbirths. The purpose of this study is to analyze the lung and brainstem development in sudden unexplained perinatal death and sudden infant death syndrome (SIDS). A total of 51 cases were investigated. A complete autopsy was performed in each case. Anatomo-pathologic examination of the central autonomic nervous system included an in-depth study on histological serial sections of the brains where the main structures participating in control of the vital functions are located. The stage of lung development was evaluated by macroscopic and microscopic criteria. In 52.9% of cases, a pulmonary hypoplasia was detected. The pulmonary hypoplasia was significantly more frequent in the SIDS group compared to the sudden perinatal unexplained death groups (p < 0.05). In 72.5% of cases, histological examination of the brainstem on serial sections showed hypodevelopment of the brainstem nuclei, particularly hypoplasia, of the arcuate nucleus (60.8%). In 47.1% of cases, pulmonary hypoplasia was associated with brainstem hypodevelopment.
Giulia Ottaviani; Rosaria Mingrone; Anna M Lavezzi; Luigi Matturri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-14
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  454     ISSN:  1432-2307     ISO Abbreviation:  Virchows Arch.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-31     Completed Date:  2009-08-18     Revised Date:  2009-08-20    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  451-6     Citation Subset:  IM    
Lino Rossi Research Center for the study and prevention of the unexpected perinatal death and SIDS, University of Milan, Milan, Italy.
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MeSH Terms
Brain Diseases / pathology*
Brain Stem / pathology*
Infant, Newborn
Lung Diseases / pathology*
Sudden Infant Death / etiology*,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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