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Infant outcomes among pregnant women who used oseltamivir for treatment of influenza during the H1N1 epidemic.
MedLine Citation:
PMID:  23333544     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: This study was undertaken to examine the association between maternal oseltamivir treatment for influenza and infant outcomes during the 2009 HINI influenza pandemic. METHODS: This was a retrospective cohort study using a population-based maternal newborn database including women who gave birth to a singleton infant in the Canadian province of Ontario between November 2009 and April 2010. Risks of small for gestational age (SGA, 10 (th) percentile and 3 (rd) percentile), preterm birth (<37 weeks of gestation), very preterm birth (<32 weeks of gestation), and five-minute Apgar score<7 associated with maternal exposure to oseltamivir were analyzed by multivariable regression. RESULTS: A total of 55,355 women with a singleton birth were included in this study. Among them, 1,237(2.2%) women received oseltamivir for treatment or prevention of influenza during pregnancy. Women who took oseltamivir during pregnancy were less likely to have a SGA infant based on the 10 (th) percentile for growth (aRR 0.77; 95% confidence interval (CI) 0.60-0.98). No association between maternal use of oseltamivir with SGA on 3 (rd) percentile , preterm birth, very preterm birth and low Apgar score was observed. CONCLUSION: There is no evidence of an association between maternal use of oseltamivir for influenza and early birth, low Apgar at birth, and poor fetal growth.
Authors:
Hai-Yan Xie; Abdool S Yasseen; Ri-Hua Xie; Deshayne B Fell; Ann E Sprague; Ning Liu; Graeme N Smith; Mark C Walker; Shi Wu Wen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  -     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Mosby, Inc. All rights reserved.
Affiliation:
OMNI Research Group, Department of Obstetrics & Gynecology, University of Ottawa, Ottawa, Canada; Changsha Social Work College, Hunan, P.R. China; Ottawa Hospital Research Institute, Clinical Epidemiology Program, Ottawa, Canada.
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