Document Detail

Infant outcome of 957 singletons born after frozen embryo replacement: the Danish National Cohort Study 1995-2006.
MedLine Citation:
PMID:  19647236     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine infant outcome of singletons born after cryopreservation of embryos (Cryo). DESIGN: National population-based controlled follow-up study. SETTING: Denmark, 1995-2007. PATIENT(S): The study population was 957 Cryo singletons (Cryo-IVF, n=660; Cryo-ICSI, n=244; Cryo-IVF/-ICSI, n=53). The first control group was all singletons born after fresh IVF or intracytoplasmic sperm injection (ICSI) during the same period (IVF, n=6904; ICSI, n=3425). The second control group comprised a random sample of non-assisted reproductive technology (ART) singletons (n=4800). INTERVENTION(S): All observations were obtained from national registers. MAIN OUTCOME MEASURE(S): Low birth weight (LBW; <2500 g), preterm birth (PTB; <37 weeks), congenital malformations, mortality, and morbidity. RESULT(S): Birth weight was higher in Cryo (mean=3578 g, SD=625) versus fresh (mean=3373 g, SD=648) and in Cryo versus non-ART (mean=3537 g, SD=572), and this was also the case for first birth only. Lower adjusted risk of LBW (odds ratio [OR]=0.63; 95% confidence interval [CI], 0.45-0.87) and PTB (OR=0.70; 95% CI, 0.53-0.92) was observed in Cryo versus fresh. Similar LBW and PTB rates were observed when comparing Cryo with non-ART, but the perinatal mortality rate was doubled in Cryo (1.6%) compared with non-ART (0.8%) singletons, and the adjusted risks of very preterm birth (<34 weeks) and neonatal admittance were also significantly increased. No significant differences in the prevalence rates of birth defects, neurological sequelae, malignancies, and imprinting-related diseases were observed between the Cryo and the two control groups. However higher malformation and cerebral palsy rates were observed in the total Fresh vs. non-ART group. CONCLUSION(S): Cryo singletons have better neonatal outcome than offspring after fresh ET but poorer compared with non-ART singletons.
Anja Pinborg; Anne Loft; Anna-Karina Aaris Henningsen; Steen Rasmussen; Anders Nyboe Andersen
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2009-07-31
Journal Detail:
Title:  Fertility and sterility     Volume:  94     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-27     Completed Date:  2010-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1320-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
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MeSH Terms
Birth Weight / physiology
Child Development / physiology
Cohort Studies
Congenital Abnormalities / epidemiology
Denmark / epidemiology
Embryo Transfer / methods,  statistics & numerical data*
Embryo, Mammalian*
Follow-Up Studies
Infant Mortality
Infant, Newborn
Live Birth / epidemiology*
Outcome Assessment (Health Care)
Perinatal Mortality

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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