| Infant outcome of 957 singletons born after frozen embryo replacement: the Danish National Cohort Study 1995-2006. | |
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MedLine Citation:
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PMID: 19647236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine infant outcome of singletons born after cryopreservation of embryos (Cryo). DESIGN: National population-based controlled follow-up study. SETTING: Denmark, 1995-2007. PATIENT(S): The study population was 957 Cryo singletons (Cryo-IVF, n=660; Cryo-ICSI, n=244; Cryo-IVF/-ICSI, n=53). The first control group was all singletons born after fresh IVF or intracytoplasmic sperm injection (ICSI) during the same period (IVF, n=6904; ICSI, n=3425). The second control group comprised a random sample of non-assisted reproductive technology (ART) singletons (n=4800). INTERVENTION(S): All observations were obtained from national registers. MAIN OUTCOME MEASURE(S): Low birth weight (LBW; <2500 g), preterm birth (PTB; <37 weeks), congenital malformations, mortality, and morbidity. RESULT(S): Birth weight was higher in Cryo (mean=3578 g, SD=625) versus fresh (mean=3373 g, SD=648) and in Cryo versus non-ART (mean=3537 g, SD=572), and this was also the case for first birth only. Lower adjusted risk of LBW (odds ratio [OR]=0.63; 95% confidence interval [CI], 0.45-0.87) and PTB (OR=0.70; 95% CI, 0.53-0.92) was observed in Cryo versus fresh. Similar LBW and PTB rates were observed when comparing Cryo with non-ART, but the perinatal mortality rate was doubled in Cryo (1.6%) compared with non-ART (0.8%) singletons, and the adjusted risks of very preterm birth (<34 weeks) and neonatal admittance were also significantly increased. No significant differences in the prevalence rates of birth defects, neurological sequelae, malignancies, and imprinting-related diseases were observed between the Cryo and the two control groups. However higher malformation and cerebral palsy rates were observed in the total Fresh vs. non-ART group. CONCLUSION(S): Cryo singletons have better neonatal outcome than offspring after fresh ET but poorer compared with non-ART singletons. |
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Authors:
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Anja Pinborg; Anne Loft; Anna-Karina Aaris Henningsen; Steen Rasmussen; Anders Nyboe Andersen |
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Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2009-07-31 |
Journal Detail:
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Title: Fertility and sterility Volume: 94 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-27 Completed Date: 2010-09-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1320-7 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. pinborg@nru.dk |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Birth Weight / physiology Child Development / physiology Cohort Studies Congenital Abnormalities / epidemiology Cryopreservation Denmark / epidemiology Embryo Transfer / methods, statistics & numerical data* Embryo, Mammalian* Female Follow-Up Studies Freezing* Humans Infant Mortality Infant, Newborn Live Birth / epidemiology* Male Outcome Assessment (Health Care) Perinatal Mortality Pregnancy |
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