Document Detail

Infant mortality in myotonic dystrophy in Saguenay-Lac-St-Jean: a historical perspective.
MedLine Citation:
PMID:  8462193     Owner:  NLM     Status:  MEDLINE    
Infant mortality among children born to 373 individuals with myotonic dystrophy (MD) who lived in Saguenay-Lac-St-Jean during the period 1838 to the present time was analyzed using a case-control approach based on a population register. A statistically significant increase was found in the rate of deaths during the first week of life among children born to MD mothers (57.5%) compared to control mothers (34.8%) and MD fathers (39.1%) (p < 0.01). The stillbirth rate was not increased. The rate of mortality after the first week fell significantly in both MD and control groups during the period of observation. There was evidence of a slight selective disadvantage among this MD population.
T N Dao; J Mathieu; J P Bouchard; M De Braekeleer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical genetics     Volume:  43     ISSN:  0009-9163     ISO Abbreviation:  Clin. Genet.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-04-30     Completed Date:  1993-04-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0253664     Medline TA:  Clin Genet     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  25-7     Citation Subset:  IM    
Département des Sciences Humaines, Université du Québec à Chicoutimi, Canada.
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MeSH Terms
Case-Control Studies
Child, Preschool
Fetal Death
Infant, Newborn
Myotonic Dystrophy / mortality*

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