Document Detail

Infant genotype may moderate sensitivity to maternal affective communications: attachment disorganization, quality of care, and the DRD4 polymorphism.
MedLine Citation:
PMID:  18167517     Owner:  NLM     Status:  MEDLINE    
Disorganized attachment is an early predictor of the development of psychopathology in childhood and adolescence. Lyons-Ruth et al. (1999) developed the AMBIANCE coding scheme to assess disrupted communication between mother and infant, and reported the link between maternal behavior and disorganized attachment. The Hungarian group found an association between a polymorphism of the DRD4 gene and disorganized attachment (Lakatos et al., 2000; 2002; Gervai et al., 2005). The present collaborative work investigated the interplay between genetic and caregiving contributions to disorganized attachment. 138 mother-infant dyads, 96 from a Hungarian low-social-risk sample and 42 from a US high-social-risk sample, were assessed for infant disorganized attachment behavior, for DRD4 gene polymorphisms, and for disrupted forms of maternal affective communication with the infant. In accord with literature reports, we found a robust main effect of maternal AMBIANCE scores on infant disorganization. However, this relation held only for the majority of infants who carried the short form of the DRD4 allele. Among carriers of the 7-repeat DRD4 allele, there was no relation between quality of maternal communication and infant disorganization. This interaction effect was independent of degree of social risk and maternal DRD4 genotype.
Judit Gervai; Alexa Novak; Krisztina Lakatos; Ildiko Toth; Ildiko Danis; Zsolt Ronai; Zsofia Nemoda; Maria Sasvari-Szekely; Jean-Francois Bureau; Elisa Bronfman; Karlen Lyons-Ruth
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Social neuroscience     Volume:  2     ISSN:  1747-0927     ISO Abbreviation:  Soc Neurosci     Publication Date:  2007  
Date Detail:
Created Date:  2008-07-17     Completed Date:  2008-12-12     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  101279009     Medline TA:  Soc Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  307-19     Citation Subset:  IM    
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MeSH Terms
Genetic Variation / genetics
Infant Behavior / physiology*,  psychology
Infant Care / psychology,  standards*
Maternal Behavior / physiology*,  psychology
Mother-Child Relations*
Parenting / psychology
Polymorphism, Genetic / genetics*
Receptors, Dopamine D4 / genetics*
Grant Support
R01 MH062030/MH/NIMH NIH HHS; R01 MH062030-04/MH/NIMH NIH HHS; R01062030//PHS HHS; R03 TW006014/TW/FIC NIH HHS; R03 TW006014-03/TW/FIC NIH HHS; R0306014//PHS HHS
Reg. No./Substance:
0/DRD4 protein, human; 137750-34-6/Receptors, Dopamine D4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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