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Infant exposure to dioxin-like compounds in breast milk.
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MedLine Citation:
PMID:  12055063     Owner:  NLM     Status:  MEDLINE    
We used a one-compartment, first-order pharmacokinetic model to predict the infant body burden of dioxin-like compounds that results from breast-feeding. Validation testing of the model showed a good match between predictions and measurements of dioxin toxic equivalents (TEQs) in breast-fed infants, and the exercise highlighted the importance of the assumption of the rate of dissipation of TEQs in the infant. We evaluated five nursing scenarios: no nursing (i.e., formula only), and nursing for 6 weeks, 6 months, 1 year, and 2 years. We assumed that an infant weighs 3.3 kg at birth and is exposed to a total of 800 pg TEQ/day by consumption of breast milk, leading to an estimated body weight-based dose of 242 pg TEQ/kg-day, which drops to 18 pg TEQ/kg-day after 1 year. This decline is due to declines in dioxin concentration in mother's milk and infant body weight increases. This range is significantly higher, on a body-weight basis, than adult TEQ exposure, which has been estimated to average about 1 pg TEQ/kg-day. For the nursing scenarios of >or= 6 months, we predict that body burdens (expressed as a body lipid concentration) peak at around 9 weeks at 44 ppt TEQ lipid. We predict that the body burden of the formula-fed infants will remain below 10 ppt TEQ lipid during the first year. These results compare to the current adult average body burden of 25 ppt TEQ lipid. We also found that an infant who had been breast-fed for 1 year had an accumulated dose 6 times higher than a 1-year-old infant who had not been breast-fed. For a 70-year lifetime, individuals who had been breast-fed had an accumulated dose 3-18% higher than individuals who had not been breast-fed.
Matthew Lorber; Linda Phillips
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental health perspectives     Volume:  110     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-10     Completed Date:  2002-07-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  United States    
Other Details:
Languages:  eng     Pagination:  A325-32     Citation Subset:  IM    
National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC 20460, USA.
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MeSH Terms
Body Burden
Body Weight
Breast Feeding*
Dioxins / analysis*,  pharmacokinetics
Environmental Exposure*
Environmental Pollutants / analysis*,  pharmacokinetics
Infant Welfare*
Infant, Newborn
Milk, Human / chemistry*
Models, Chemical
Time Factors
Reg. No./Substance:
0/Dioxins; 0/Environmental Pollutants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 6 Year: 2002
Volume: 110 Issue: 6
First Page: A325 Last Page: A332
ID: 1240886
PubMed Id: 12055063
Publisher Item Identifier: sc271_5_1835

Infant exposure to dioxin-like compounds in breast milk.
Matthew Lorber
Linda Phillips
National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC 20460, USA.

Article Categories:
  • Research Article

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