Document Detail


Infant exposure of perfluorinated compounds: levels in breast milk and commercial baby food.
MedLine Citation:
PMID:  20494442     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, an analytical method to determine six perfluorinated compounds (PFCs) based on alkaline digestion and solid phase extraction (SPE) followed by liquid chromatography-quadrupole-linear ion trap mass spectrometry (LC-QqLIT-MS) was validated for the analysis of human breast milk, milk infant formulas and cereals baby food. The average recoveries of the different matrices were in general higher than 70% with a relative standard deviation (RSD) lower than 21% and method limits of detection (MLOD) ranging from 1.2 to 362 ng/L for the different compounds and matrices. The method was applied to investigate the occurrence of PFCs in 20 samples of human breast milk, and 5 samples of infant formulas and cereal baby food (3 brands of commercial milk infant formulas and 2 brands of cereals baby food). Breast milk samples were collected in 2008 from donors living in Barcelona city (Spain) on the 40 days postpartum. Perfluorooctanesulfonate (PFOS) and perfluoro-7-methyloctanoic acid (i,p-PFNA) were predominant being present in the 95% of breast milk samples. Perfluorooctanoic acid (PFOA) was quantified in 8 of the 20 breast milk samples at concentrations in the range of 21-907 ng/L. Commercial formulas and food were purchased also in 2009 from a retail store. The six PFCs were detected in all brands of milk infant formulas and cereals baby food analyzed, being perfluorodecanoic acid (PFDA), PFOS, PFOA and i,p-PFNA the compounds detected in higher concentrations (up to 1289 ng/kg). PFCs presence can be associated to possible migration from packaging and containers during production processes. Finally, based on estimated body weight and newborn intake, PFOS and PFOA daily intakes and risk indexes (RI) were estimated for the firsts 6 month of life. We found that ingestion rates of PFOS and PFOA, with exception of one breast milk sample did not exceed the tolerable daily intake (TDI) recommended by the EFSA. However, more research is needed in order to assess possible risk associated to PFCs contamination during early stages of life.
Authors:
Marta Llorca; Marinella Farré; Yolanda Picó; Marisa Lopez Teijón; Juan G Alvarez; Damià Barceló
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-21
Journal Detail:
Title:  Environment international     Volume:  36     ISSN:  1873-6750     ISO Abbreviation:  Environ Int     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-06-11     Completed Date:  2010-08-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7807270     Medline TA:  Environ Int     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  584-92     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Environmental Chemistry, IDAEA-CSIC, Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Chromatography, Liquid
Environmental Exposure / analysis*
Environmental Monitoring / methods*
Environmental Pollutants / analysis*,  metabolism
Female
Fluorocarbons / analysis*,  metabolism
Humans
Infant
Infant Food / analysis*
Milk, Human / metabolism*
Octanoic Acids / analysis
Solid Phase Extraction
Tandem Mass Spectrometry
Chemical
Reg. No./Substance:
0/Environmental Pollutants; 0/Fluorocarbons; 0/Octanoic Acids; 335-67-1/perfluorooctanoic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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