Document Detail


Infant cold exposure changes Fos expression to acute cold stimulation in adult hypothalamic brain regions.
MedLine Citation:
PMID:  9809667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is known that cold exposure as an infant results in a permanent cold tolerance which is accompanied by a reduced rate of colonic temperature decline and increased metabolic heat production to cold stimulation. The present study was aimed to elucidate the central mechanism of cold tolerance of adult rats with cold exposure as infants. Newborn infants were exposed to cold ambient (4 degrees C) daily for 2 weeks, and when they were 15-weeks old, Fos expression to acute cold stimulation (10 degrees C) in whole brain regions was investigated using quantitative immunohistochemistry. Acute cold stimulation induced a significant increase of Fos-positive neurons in many nuclei of whole brain areas in adult rats both with and without cold exposure as infants. However, the number of Fos-positive neurons was significantly less in the rats with cold exposure than without cold exposure as infants, particularly in the hypothalamic nuclei such as the lateral septal nucleus (LS), preoptic area (POA), parvocellular paraventricular nucleus (pPVN0, ventromedial hypothalamic nucleus (VMH) and supramammillary nucleus (SuM). However, there was no significant difference in the number of Fos-positive neurons in the extra-hypothalamic regions between the rats with and without cold exposure as infants. These results suggest that the central mechanism of cold tolerance with cold exposure as infants is due to metabolic changes of the hypothalamic brain regions.
Authors:
S Miyata; M Ishiyama; M Shibata; T Nakashima; T Kiyohara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience research     Volume:  31     ISSN:  0168-0102     ISO Abbreviation:  Neurosci. Res.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1999-02-05     Completed Date:  1999-02-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8500749     Medline TA:  Neurosci Res     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  219-25     Citation Subset:  IM    
Affiliation:
Department of Applied Biology, Kyoto Institute of Technology, Japan. smiyata@ipc.kit.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / physiology*
Cold Temperature / adverse effects*
Gene Expression Regulation, Developmental / physiology*
Genes, fos / physiology*
Hypothalamus / physiology*
Immunohistochemistry
Male
Neurons / metabolism,  physiology
Rats
Rats, Wistar

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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