Document Detail


Infant brain atlases from neonates to 1- and 2-year-olds.
MedLine Citation:
PMID:  21533194     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Studies for infants are usually hindered by the insufficient image contrast, especially for neonates. Prior knowledge, in the form of atlas, can provide additional guidance for the data processing such as spatial normalization, label propagation, and tissue segmentation. Although it is highly desired, there is currently no such infant atlas which caters for all these applications. The reason may be largely due to the dramatic early brain development, image processing difficulties, and the need of a large sample size.
METHODOLOGY: To this end, after several years of subject recruitment and data acquisition, we have collected a unique longitudinal dataset, involving 95 normal infants (56 males and 39 females) with MRI scanned at 3 ages, i.e., neonate, 1-year-old, and 2-year-old. State-of-the-art MR image segmentation and registration techniques were employed, to construct which include the templates (grayscale average images), tissue probability maps (TPMs), and brain parcellation maps (i.e., meaningful anatomical regions of interest) for each age group. In addition, the longitudinal correspondences between age-specific atlases were also obtained. Experiments of typical infant applications validated that the proposed atlas outperformed other atlases and is hence very useful for infant-related studies.
CONCLUSIONS: We expect that the proposed infant 0-1-2 brain atlases would be significantly conducive to structural and functional studies of the infant brains. These atlases are publicly available in our website, http://bric.unc.edu/ideagroup/free-softwares/.
Authors:
Feng Shi; Pew-Thian Yap; Guorong Wu; Hongjun Jia; John H Gilmore; Weili Lin; Dinggang Shen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-04-14
Journal Detail:
Title:  PloS one     Volume:  6     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-02     Completed Date:  2011-08-30     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e18746     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Atlases as Topic*
Brain / anatomy & histology*
Child, Preschool
Female
Humans
Infant
Infant, Newborn
Magnetic Resonance Imaging
Male
Grant Support
ID/Acronym/Agency:
EB006733/EB/NIBIB NIH HHS; EB008374/EB/NIBIB NIH HHS; EB008760/EB/NIBIB NIH HHS; EB009634/EB/NIBIB NIH HHS; HD053000/HD/NICHD NIH HHS; MH064065/MH/NIMH NIH HHS; MH070890/MH/NIMH NIH HHS; MH088520/MH/NIMH NIH HHS; NS055754/NS/NINDS NIH HHS; R01 EB006733/EB/NIBIB NIH HHS; R01 EB006733-01A2/EB/NIBIB NIH HHS; R01 EB008374-01A2/EB/NIBIB NIH HHS; R01 HD053000-01A1/HD/NICHD NIH HHS; R01 MH070890-01/MH/NIMH NIH HHS; R01 NS055754-01A1/NS/NINDS NIH HHS; RC1 MH088520-01/MH/NIMH NIH HHS
Comments/Corrections

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