Document Detail


Infant botulism.
MedLine Citation:
PMID:  17314986     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Infant botulism results from the absorption of heat-labile neurotoxin produced in situ by ingested Clostridium botulinum. Honey and environmental exposure are the main sources of acquisition of the organism. Clinical manifestations are owing to progressive neuromuscular blockade, initially of muscles innervated by cranial nerves and later of the trunk, extremities and diaphragm. Presynaptic autonomic nerves are also affected. The diagnosis is made on clinical grounds and is confirmed by recovery of the organism or by detection of toxin in the stool. Management includes meticulous supportive intensive care that may include mechanical ventilation and administration of human botulinum immunoglobulin in severe cases.
Authors:
I Brook
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  27     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-22     Completed Date:  2007-04-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  175-80     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Georgetown University School of Medicine, Washington, DC 20016, USA. IB6@georgetown.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Botulism / diagnosis*,  epidemiology,  etiology,  prevention & control,  therapy*
Breast Feeding
Clostridium botulinum / isolation & purification,  physiology
Diagnosis, Differential
Humans
Infant
Infant Formula
Nutritional Support
Risk Factors
Seasons
Spores, Fungal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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