Document Detail


Infant acute lymphoblastic leukaemia with t(11; 19).
MedLine Citation:
PMID:  2334635     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Seven cases of infant acute lymphoblastic leukaemia with t(11; 19) (q23; p13) are described. They are characterized by a high white cell count, organomegaly, early central nervous system (CNS) disease, and a poor prognosis. Blasts are usually of an immature early B-cell lineage although monocytoid features are present in some cases. The characteristics of infant acute leukaemia with t(11; 19) are very similar to those found with t(4; 11), and the presence of t(11; 19) may indicate the same poor prognosis.
Authors:
B Gibbons; F E Katz; P Ganly; J M Chessells
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  74     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-06-08     Completed Date:  1990-06-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  264-9     Citation Subset:  IM    
Affiliation:
CRF Department of Medical Oncology, St. Bartholomew's Hospital, London.
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MeSH Terms
Descriptor/Qualifier:
Antigens, Neoplasm / analysis
Chromosomes, Human, Pair 11*
Chromosomes, Human, Pair 19*
Female
Gene Rearrangement, B-Lymphocyte, Heavy Chain / genetics
Humans
Infant
Infant, Newborn
Karyotyping
Leukocyte Count
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*,  immunology,  pathology
Prognosis
Translocation, Genetic / genetics*
Chemical
Reg. No./Substance:
0/Antigens, Neoplasm

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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