| Infant sleep after immunization: randomized controlled trial of prophylactic acetaminophen. | |
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MedLine Citation:
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PMID: 22123869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the effects of acetaminophen and axillary temperature responses on infant sleep duration after immunization. METHODS: We conducted a prospective, randomized controlled trial to compare the sleep of 70 infants monitored by using ankle actigraphy for 24 hours before and after their first immunization series at ∼2 months of age. Mothers of infants in the control group received standard care instructions from their infants' health care provider, and mothers of infants in the intervention group were provided with predosed acetaminophen and instructed to administer a dose 30 minutes before the scheduled immunization and every 4 hours thereafter, for a total of 5 doses. Infant age and birth weight and immunization factors, such as acetaminophen use and timing of administration, were evaluated for changes in infant sleep times after immunization. RESULTS: Sleep duration in the first 24 hours after immunization was increased, particularly for infants who received their immunizations after 1:30 pm and for those who experienced elevated temperatures in response to the vaccines. Infants who received acetaminophen at or after immunization had smaller increases in sleep duration than did infants who did not. However, acetaminophen use was not a significant predictor of sleep duration when other factors were controlled. CONCLUSIONS: If further research confirms the relationship between time of day of vaccine administration, increased sleep duration after immunization, and antibody responses, then our findings suggest that afternoon immunizations should be recommended to facilitate increased sleep in the 24 hours after immunization, regardless of acetaminophen administration. |
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Authors:
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Linda Franck; Caryl L Gay; Mary Lynch; Kathryn A Lee |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2011-11-28 |
Journal Detail:
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Title: Pediatrics Volume: 128 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-02 Completed Date: 2012-01-24 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
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Languages: eng Pagination: 1100-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Family Health Care Nursing, University of California, San Francisco, CA 94143-0606, USA. linda.franck@nursing.ucsf.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT01321710 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetaminophen
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therapeutic use* Antipyretics / therapeutic use* Double-Blind Method Female Humans Immunization* Infant Male Prospective Studies Sleep / drug effects* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01 NR05345/NR/NINR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antipyretics; 103-90-2/Acetaminophen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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