Document Detail

Infant sleep after immunization: randomized controlled trial of prophylactic acetaminophen.
MedLine Citation:
PMID:  22123869     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the effects of acetaminophen and axillary temperature responses on infant sleep duration after immunization.
METHODS: We conducted a prospective, randomized controlled trial to compare the sleep of 70 infants monitored by using ankle actigraphy for 24 hours before and after their first immunization series at ∼2 months of age. Mothers of infants in the control group received standard care instructions from their infants' health care provider, and mothers of infants in the intervention group were provided with predosed acetaminophen and instructed to administer a dose 30 minutes before the scheduled immunization and every 4 hours thereafter, for a total of 5 doses. Infant age and birth weight and immunization factors, such as acetaminophen use and timing of administration, were evaluated for changes in infant sleep times after immunization.
RESULTS: Sleep duration in the first 24 hours after immunization was increased, particularly for infants who received their immunizations after 1:30 pm and for those who experienced elevated temperatures in response to the vaccines. Infants who received acetaminophen at or after immunization had smaller increases in sleep duration than did infants who did not. However, acetaminophen use was not a significant predictor of sleep duration when other factors were controlled.
CONCLUSIONS: If further research confirms the relationship between time of day of vaccine administration, increased sleep duration after immunization, and antibody responses, then our findings suggest that afternoon immunizations should be recommended to facilitate increased sleep in the 24 hours after immunization, regardless of acetaminophen administration.
Linda Franck; Caryl L Gay; Mary Lynch; Kathryn A Lee
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2011-11-28
Journal Detail:
Title:  Pediatrics     Volume:  128     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-02     Completed Date:  2012-01-24     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1100-8     Citation Subset:  AIM; IM    
Department of Family Health Care Nursing, University of California, San Francisco, CA 94143-0606, USA.
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MeSH Terms
Acetaminophen / therapeutic use*
Antipyretics / therapeutic use*
Double-Blind Method
Prospective Studies
Sleep / drug effects*
Time Factors
Grant Support
Reg. No./Substance:
0/Antipyretics; 103-90-2/Acetaminophen

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