Document Detail


Infant CD4 C868T polymorphism is associated with increased human immunodeficiency virus (HIV-1) acquisition.
MedLine Citation:
PMID:  20132229     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The C868T single nucleotide polymorphism (SNP) in the CD4 receptor encodes an amino acid change that could alter its structure and influence human immunodeficiency virus (HIV-1) infection risk. HIV-1-infected pregnant women in Nairobi were followed with their infants for 1 year postpartum. Among 131 infants, those with the 868T allele were more likely than wild-type infants to acquire HIV-1 overall [hazard ratio (HR) = 1.92, 95% confidence interval (CI) 1.05, 3.50, P = 0.03; adjusted HR = 2.03, 95% CI 1.03, 3.98, P = 0.04], after adjusting for maternal viral load. This SNP (an allele frequency of approximately 15% in our cohort) was associated with increased susceptibility to mother-to-child HIV-1 transmission, consistent with a previous study on this polymorphism among Nairobi sex workers.
Authors:
R Y Choi; C Farquhar; J Juno; D Mbori-Ngacha; B Lohman-Payne; F Vouriot; S Wayne; J Tuff; R Bosire; G John-Stewart; K Fowke
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-02-02
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  160     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-18     Completed Date:  2010-07-09     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  461-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Alleles*
Antigens, CD4 / genetics*,  immunology
Cohort Studies
Female
Gene Frequency*
HIV Infections / genetics*,  immunology,  transmission*
HIV-1*
Humans
Infant
Infectious Disease Transmission, Vertical*
Polymorphism, Single Nucleotide*
Pregnancy
Pregnancy Complications, Infectious / drug therapy,  genetics,  immunology,  virology
Grant Support
ID/Acronym/Agency:
D43 TW000007/TW/FIC NIH HHS; HD-23412/HD/NICHD NIH HHS; HOP-75348//Canadian Institutes of Health Research; K24 HD054314/HD/NICHD NIH HHS; MDP-86721//Canadian Institutes of Health Research; P30 AI027757/AI/NIAID NIH HHS; R24 TW007988/TW/FIC NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD4
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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