| Infant CD4 C868T polymorphism is associated with increased human immunodeficiency virus (HIV-1) acquisition. | |
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MedLine Citation:
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PMID: 20132229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The C868T single nucleotide polymorphism (SNP) in the CD4 receptor encodes an amino acid change that could alter its structure and influence human immunodeficiency virus (HIV-1) infection risk. HIV-1-infected pregnant women in Nairobi were followed with their infants for 1 year postpartum. Among 131 infants, those with the 868T allele were more likely than wild-type infants to acquire HIV-1 overall [hazard ratio (HR) = 1.92, 95% confidence interval (CI) 1.05, 3.50, P = 0.03; adjusted HR = 2.03, 95% CI 1.03, 3.98, P = 0.04], after adjusting for maternal viral load. This SNP (an allele frequency of approximately 15% in our cohort) was associated with increased susceptibility to mother-to-child HIV-1 transmission, consistent with a previous study on this polymorphism among Nairobi sex workers. |
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Authors:
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R Y Choi; C Farquhar; J Juno; D Mbori-Ngacha; B Lohman-Payne; F Vouriot; S Wayne; J Tuff; R Bosire; G John-Stewart; K Fowke |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-02-02 |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 160 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-18 Completed Date: 2010-07-09 Revised Date: 2013-02-08 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 461-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Washington, Seattle, WA 98104, USA. ryc@u.washington.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alleles* Antigens, CD4 / genetics*, immunology Cohort Studies Female Gene Frequency* HIV Infections / genetics*, immunology, transmission* HIV-1* Humans Infant Infectious Disease Transmission, Vertical* Polymorphism, Single Nucleotide* Pregnancy Pregnancy Complications, Infectious / drug therapy, genetics, immunology, virology |
| Grant Support | |
ID/Acronym/Agency:
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D43 TW000007/TW/FIC NIH HHS; HD-23412/HD/NICHD NIH HHS; HOP-75348//Canadian Institutes of Health Research; K24 HD054314/HD/NICHD NIH HHS; K24 HD054314-04/HD/NICHD NIH HHS; K24 HD054314-05/HD/NICHD NIH HHS; MDP-86721//Canadian Institutes of Health Research; P30 AI027757/AI/NIAID NIH HHS; R24 TW007988/TW/FIC NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD4 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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