| Inefficient arterial hypertension control in patients with metabolic syndrome and its link to renin-angiotensin-aldosterone system polymorphisms. | |
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MedLine Citation:
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PMID: 21471972 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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There is evidence that uncontrolled arterial hypertension (AHT) in patients with metabolic syndrome (MS) increases cardiovascular risks. The renin-angiotensin-aldosterone system (RAAS) and its polymorphisms apparently confer a genetic risk for uncontrolled AHT. This study aims to investigate the influence of RAAS polymorphisms on AHT control in patients diagnosed with MS. This is a two-stage population-based nested case-control pilot study (n=1514). We differentiated between MS-diagnosed patients and non-MS patients (ATP-III criteria) and selected those individuals diagnosed with AHT from each group (n=161 and n=156, respectively). Those who successfully controlled their AHT (controls) and those who did not were compared. In the MS population, the C/G and G/G genotypes of single-nucleotide polymorphism rs1040288 (NR3C2) and A/G and G/G of rs11099680 (NR3C2) were associated with uncontrolled AHT (odds ratio (OR)=2.94 (1.34-6.47) and OR=2.54 (1.09-5.93), respectively). According to Akaike's information criteria, the best adjusted model included gender and age as confounding variables (adjusted OR (ORa)=2.91 (1.31-6.46) and ORa=2.67 (1.13-6.31), respectively). Regarding rs1040288, an ORa of 4.03 (1.44-11.26) was obtained for the saturated model (adjusted for gender, age, waist-to-hip ratio, body mass index, biochemical profile, renal damage, smoking habit and anti-AHT treatment). Yet, when the same analysis was performed on the non-MS population, no association was found between rs11099680 and the failure to control AHT. The results reveal a possible association between the rs11099680 RAAS polymorphism and uncontrolled AHT in MS-diagnosed patients. rs1040288 appears to be associated with uncontrolled blood pressure regardless of MS profile.Hypertension Research advance online publication, 7 April 2011; doi:10.1038/hr.2011.37. |
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Authors:
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Maria M Morales-Suárez-Varela; Maria L Mansego; Ana M Vicedo-Cabrera; Monica Pineda-Alonso; Aqustin Llopis-González; Jose M Martin-Moreno; Juan C Martín-Escudero; F J Chaves |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-07 |
Journal Detail:
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Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: - ISSN: 1348-4214 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9307690 Medline TA: Hypertens Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1] Department of Preventive Medicine, Unit of Public Health and Environmental Care, University of Valencia, Valencia, Spain [2] CIBER Epidemiology and Public Health, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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