Document Detail

Inefficacy of propranolol in attenuation of drug-induced parkinsonian tremor.
MedLine Citation:
PMID:  8093548     Owner:  NLM     Status:  MEDLINE    
We investigated the tremolytic effect of long-acting propranolol (propranolol-LA) in six subjects with drug-induced parkinsonism (DIP), using a double-blind, placebo-controlled, crossover experimental design. Subjects received propranolol-LA for 2 weeks and placebo for 2 weeks, with no change in neuroleptic treatment. Tremor frequency and amplitude were objectively quantified at the end of each 2-week period by computerized tremorgram recording. There were no significant differences in attenuation of DIP tremor by propranolol-LA and placebo. Previous investigations reported in the literature have found propranolol to attenuate the tremor of idiopathic parkinsonism (IPD). It is expected that DIP and IPD tremor would respond similarly to propranolol if a solely peripheral or spinal cord tremolytic action were operative. A possible differential attenuation of IPD tremor and DIP tremor provides support for the concept of a higher central tremolytic mechanism of beta-adrenergic receptor-blocking drugs.
W S Metzer; S R Paige; J E Newton
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  8     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  1993  
Date Detail:
Created Date:  1993-02-11     Completed Date:  1993-02-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  43-6     Citation Subset:  IM    
Department of Neurology, University of Arkansas for Medical Science, Little Rock.
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MeSH Terms
Antipsychotic Agents / adverse effects*,  therapeutic use
Chronic Disease
Double-Blind Method
Drug Therapy, Combination
Dyskinesia, Drug-Induced / drug therapy*
Fourier Analysis
Middle Aged
Neurologic Examination / drug effects,  instrumentation
Parkinson Disease, Secondary / chemically induced*,  drug therapy
Propranolol / adverse effects,  therapeutic use*
Schizophrenia / drug therapy*
Schizophrenic Psychology*
Signal Processing, Computer-Assisted / instrumentation
Tremor / chemically induced*,  drug therapy
Reg. No./Substance:
0/Antipsychotic Agents; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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