| Inefficacy of intestinal secretory immune response to Cryptosporidium in acquired immunodeficiency syndrome. | |
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MedLine Citation:
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PMID: 7875465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: An alteration of the secretory immune response has been forwarded to explain frequent and chronic mucosal infections in patients with acquired immunodeficiency syndrome (AIDS). The aim of this study was to explore the intestinal immunoglobulin (Ig) secretions in patients with AIDS and their relationships to cryptosporidiosis. METHODS: Patients with AIDS and enteric cryptosporidiosis (n = 12), other enteric infections (n = 10), and no identifiable enteric pathogen (n = 10) and human immunodeficiency virus-seronegative controls (n = 18) were studied. The number of intestinal IgA and IgM plasma cells of the duodenal lamina propria mucosa and total and anti-Cryptosporidium IgA, IgM, and IgG were measured in serum and feces. RESULTS: Although not significantly increased, the number of IgA and IgM plasma cells was greater in patients with AIDS (n = 20) than in controls (n = 5). In feces, total IgA outputs and specific anti-Cryptosporidium IgA levels were significantly higher in patients with AIDS and cryptosporidiosis than in the two other groups of patients with AIDS (P < 0.05 and P < 0.01, respectively) and controls (P < 0.001 and P < 0.01, respectively). Total fecal IgM output and specific anti-Cryptosporidium IgM coproantibodies were increased only in the Cryptosporidium-infected patients relative to the controls (P < 0.05). CONCLUSIONS: Despite the development of pathogen-specific mucosal antibody responses, patients with AIDS and cryptosporidiosis fail to clear the parasite. |
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Authors:
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Y Benhamou; N Kapel; C Hoang; H Matta; D Meillet; D Magne; M Raphael; M Gentilini; P Opolon; J G Gobert |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gastroenterology Volume: 108 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-04-04 Completed Date: 1995-04-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 627-35 Citation Subset: AIM; IM; X |
Affiliation:
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Service d'Hépato-Gastroentérologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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complications,
immunology* Adult Animals Antibodies, Protozoan / analysis* Antibody Formation Cell Count Cryptosporidiosis / complications Cryptosporidium / immunology* Electrophoresis, Polyacrylamide Gel Feces / chemistry Female Humans Immunoblotting Immunoglobulins / analysis Intestinal Mucosa / immunology*, secretion* Male Middle Aged Plasma Cells / pathology alpha 1-Antitrypsin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Protozoan; 0/Immunoglobulins; 0/alpha 1-Antitrypsin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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