Document Detail

Ineffectiveness of intravenous ascorbic acid as an acidifying agent in man.
MedLine Citation:
PMID:  7458517     Owner:  NLM     Status:  MEDLINE    
The acidifying effect of intravenous (IV) ascorbic acid was studied in seven healthy adult volunteers. After obtaining baseline urine and blood samples, 2-g IV doses of ascorbic acid were administered to each subject during a 20-minute period. Venous blood samples were obtained at times 0.5, 1, and 2 hours, and urine was collected at times 0.5, 1, 2, and 3 hours. Our results show that venous blood pH, plasma bicarbonate concentration, urine PCO2, and urine bicarbonate excretion did not change significantly during the study period. Urinary titratable acidity, ammonium excretion, and net hydrogen ion excretion decreased, and urinary pH actually showed a significant rise at two hours. We therefore conclude that IV ascorbic acid administered in recommended doses does not effectively acidify urine.
C H Barton; M L Sterling; R Thomas; N D Vaziri; C Byrne; G Ryan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of internal medicine     Volume:  141     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1981 Feb 
Date Detail:
Created Date:  1981-03-27     Completed Date:  1981-03-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  211-2     Citation Subset:  AIM; IM    
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MeSH Terms
Acid-Base Equilibrium / drug effects*
Acids / analysis
Ascorbic Acid / pharmacology*,  therapeutic use
Urinary Tract Infections / drug therapy
Urine / analysis*
Grant Support
09H-001393-02-0-MSH 35//PHS HHS
Reg. No./Substance:
0/Acids; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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