Document Detail

Ineffectiveness of cholecystokinin in impairing runway performance.
MedLine Citation:
PMID:  6097286     Owner:  NLM     Status:  MEDLINE    
We compared changes in runway performance by rats for sucrose reward following injections of the synthetic C-terminal octapeptide of cholecystokinin (CCK-8) with those seen after variations in food deprivation and injections of lithium chloride. No effects on running for either 10% or 30% sucrose were found following 0.5 to 4.0 micrograms/kg of CCK-8, though such doses suppressed 30-min sucrose intake up to 53%. Statistically reliable slowing of running for 10% sucrose was observed on two series of tests after 8.0 micrograms/kg of CCK-8. Running for 30% sucrose was not significantly affected by this dose. The general ineffectiveness of CCK-8 for producing decrements in running spread contrasts with significantly reduced performance after either reductions in food deprivation (21 h vs 12 and 3 h) or injections of 75 mg/kg lithium chloride. These results suggest that the mode of action of CCK-8 in reducing food intake is different than that produced by changes in hunger or by non-specific interference with motivation by malaise. The finding that CCK-8 can substantially reduce consumption with no apparent changes in appetitive motivation is consistent with the hypothesis that this substance acts only late in the meal to prematurely trigger satiety.
J E Cox; P T Brown; R J Toney; D J Wiebe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Behavioural brain research     Volume:  14     ISSN:  0166-4328     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1985-03-18     Completed Date:  1985-03-18     Revised Date:  2006-03-01    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  41-50     Citation Subset:  IM    
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MeSH Terms
Appetite / drug effects
Feeding Behavior / drug effects
Food Deprivation
Rats, Inbred Strains
Satiation / drug effects*
Satiety Response / drug effects*
Sincalide / pharmacology*
Reg. No./Substance:

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