Document Detail

Ineffective esophageal motility in gastroesophageal erosive reflux disease and in nonerosive reflux disease: are they different?
MedLine Citation:
PMID:  15718864     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In GERD patients, ineffective esophageal motility (IEM), a hypocontractile disorder, is the most common motor abnormality. IEM has been associated with reflux in both the supine and upright position, prolonged esophageal clearance, and delayed of bolus transport. IEM has been equally present in erosive and in nonerosive GERD. GOAL: Considering that reflux has been found to be more severe in erosive GERD than in nonerosive GERD patients and that IEM delays esophageal clearance, our hypothesis is that patients with erosive GERD have more severe IEM than those with nonerosive disease. STUDY: A retrospective review of consecutive manometries of patients with the chief complaint of heartburn and a diagnosis of IEM were performed, and patients with both erosive and nonerosive GERD were selected. According to the number of ineffective contractions, IEM was stratified into three groups: 30% to 40%, mild; 50% to 60%, moderate; and greater than 60%, severe. We also registered the number of low amplitude, failed, and normal waves in each manometry of both groups. We evaluated 110 patients: 70 (64%) with erosive GERD and 40 (36%) with nonerosive GERD. The percentage of mild, moderate and severe IEM was similar in erosive and in nonerosive GERD patients, as well the number of low amplitude, failed or normal waves (P < 0.5). CONCLUSION: There were no differences between the severity of IEM in erosive and in nonerosive GERD patients.
Eponina Maria de Oliveira Lemme; Luiz J Abrahão-Junior; Yolanda Manhães; Rosana Shechter; Beatriz Biccas Carvalho; Angela Alvariz
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  39     ISSN:  0192-0790     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-02-18     Completed Date:  2005-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  224-7     Citation Subset:  IM    
Division of Gastroenterology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Brazil.
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MeSH Terms
Esophageal Motility Disorders / complications*,  physiopathology*
Gastroesophageal Reflux / complications*,  physiopathology*
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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