Document Detail

Industrial production of amino acids by coryneform bacteria.
MedLine Citation:
PMID:  12948636     Owner:  NLM     Status:  MEDLINE    
In the 1950s Corynebacterium glutamicum was found to be a very efficient producer of L-glutamic acid. Since this time biotechnological processes with bacteria of the species Corynebacterium developed to be among the most important in terms of tonnage and economical value. L-Glutamic acid and L-lysine are bulk products nowadays. L-Valine, L-isoleucine, L-threonine, L-aspartic acid and L-alanine are among other amino acids produced by Corynebacteria. Applications range from feed to food and pharmaceutical products. The growing market for amino acids produced with Corynebacteria led to significant improvements in bioprocess and downstream technology as well as in molecular biology. During the last decade big efforts were made to increase the productivity and to decrease the production costs. This review gives an overview of the world market for amino acids produced by Corynebacteria. Significant improvements in bioprocess technology, i.e. repeated fed batch or continuous production are summarised. Bioprocess technology itself was improved furthermore by application of more sophisticated feeding and automatisation strategies. Even though several amino acids developed towards commodities in the last decade, side aspects of the production process like sterility or detection of contaminants still have increasing relevance. Finally one focus of this review is on recent developments in downstream technology.
Thomas Hermann
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of biotechnology     Volume:  104     ISSN:  0168-1656     ISO Abbreviation:  J. Biotechnol.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-01     Completed Date:  2004-05-19     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8411927     Medline TA:  J Biotechnol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  155-72     Citation Subset:  IM    
Degussa AG, Feed Additives, Research and Development Biotechnology, Kantstr. 2, 33790 Halle/Westf., Germany.
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MeSH Terms
Amino Acids / biosynthesis*,  economics*
Bioreactors / economics,  microbiology*
Cell Culture Techniques / economics,  methods,  trends
Corynebacterium / metabolism*
Drug Industry / economics*,  methods*,  trends
Food Industry / economics*,  methods*,  trends
Food Technology / economics,  methods
Technology, Pharmaceutical / economics,  methods,  trends
Reg. No./Substance:
0/Amino Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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