Document Detail

Industrial food animal production, antimicrobial resistance, and human health.
MedLine Citation:
PMID:  18348709     Owner:  NLM     Status:  MEDLINE    
Antimicrobial resistance is a major public health crisis, eroding the discovery of antimicrobials and their application to clinical medicine. There is a general lack of knowledge of the importance of agricultural antimicrobial use as a factor in antimicrobial resistance even among experts in medicine and public health. This review focuses on agricultural antimicrobial drug use as a major driver of antimicrobial resistance worldwide for four reasons: It is the largest use of antimicrobials worldwide; much of the use of antimicrobials in agriculture results in subtherapeutic exposures of bacteria; drugs of every important clinical class are utilized in agriculture; and human populations are exposed to antimicrobial-resistant pathogens via consumption of animal products as well as through widespread release into the environment.
Ellen K Silbergeld; Jay Graham; Lance B Price
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Annual review of public health     Volume:  29     ISSN:  0163-7525     ISO Abbreviation:  Annu Rev Public Health     Publication Date:  2008  
Date Detail:
Created Date:  2008-03-19     Completed Date:  2008-06-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006431     Medline TA:  Annu Rev Public Health     Country:  United States    
Other Details:
Languages:  eng     Pagination:  151-69     Citation Subset:  IM    
Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
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MeSH Terms
Animal Feed
Animal Husbandry / methods*,  standards
Anti-Infective Agents / administration & dosage*,  adverse effects
Drug Resistance, Microbial*
Environmental Pollution
Food Additives
Food Supply*
Meat / adverse effects
Public Health
World Health
Reg. No./Substance:
0/Anti-Infective Agents; 0/Food Additives

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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