Document Detail

Industrial air pollution and children's respiratory health: a natural experiment in Călăraşi.
MedLine Citation:
PMID:  17853183     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In 1993-1997, we described a high incidence of wheezing in children living near the iron, steel, and coke factory of Călăraşi (Romania). In 1998, the factory was closed. OBJECTIVE: To investigate the influence of closing the factory on the incidence of wheezing in children living near the factory. METHODS: We used this natural experiment to compare wheezing occurrence in children below age 2 in an area near the factory and in a village 10 km from the factory (Roseţi). We studied three birth cohorts: those 2 years old before the closing of the factory (group 1), those born before the closing and returning 2 after the closing (group 2), those born after the closing (group 3). RESULTS: The relative risk (95% CI) of having at least one episode of wheezing during the first life-year was 0.51 (0.30-0.85) in group 3 versus group 1, and 0.95 (0.64-1.40) for group 2 versus group 1. After adjusting for possible confounders, the incidence dropped in Călăraşi (odds ratio [OR] 0.38, 95% CI 0.19-0.76), while it increased in Roseţi (OR 8.36, 95% CI 1.84-38.0). Results for the 2-year incidence were similar. CONCLUSION: Industrial air pollution by the factory was the main risk factor for wheezing during the first life-years of the children of Călăraşi. Closing the factory resulted in a significant decrease in wheezing incidence rates, which still remained higher than in a nearby village.
Alexandra Carmen Câra; Frank Buntinx; Marjan Van den Akker; Geert-Jan Dinant; Carmen Manolovici
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European journal of general practice     Volume:  13     ISSN:  1381-4788     ISO Abbreviation:  Eur J Gen Pract     Publication Date:  2007  
Date Detail:
Created Date:  2007-11-30     Completed Date:  2008-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9513566     Medline TA:  Eur J Gen Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  135-43     Citation Subset:  IM    
Department of General Practice, University of Maastricht, Maastricht, The Netherlands.
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MeSH Terms
Air Pollutants / toxicity*
Air Pollution / adverse effects*
Cohort Studies
Environmental Exposure / adverse effects*
Odds Ratio
Prospective Studies
Respiratory Sounds / etiology*
Risk Assessment
Time Factors
Reg. No./Substance:
0/Air Pollutants; 0/Coke; 12597-69-2/Steel; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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