| Inductions of histone H3 acetylation at lysine 9 on SGLT1 gene and its expression by feeding mice a high carbohydrate/fat ratio diet. | |
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MedLine Citation:
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PMID: 18952408 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We examined in this study whether histone H3 acetylations on jejunal NA(+)/glucose transport-1 (SGLT1) gene are associated with induction of its gene by feeding mice a high carbohydrate/fat ratio diet. METHODS: The chromatin immunoprecipitation (ChIP) assays using antibodies of acetylated histone H3 were performed in jejunum of mice fed a high carbohydrate/fat ratio diet or a low carbohydrate/fat ratio for 7 d. RESULTS: The acetylations of histone H3 of lysine 9/14 were highly detected on the SGLT1 gene and the levels were enhanced by feeding mice a high carbohydrate/fat ratio diet. Histone H3 acetylation at lysine 9 was enhanced by feeding a high carbohydrate/fat ratio diet, whereas that at lysine 14 was not enhanced significantly. CONCLUSION: These observations indicate that induction of SGLT1 gene expression by feeding a high carbohydrate/fat ratio diet is associated with acetylation of histone H3 at lysine 9 on the SGLT1 gene. |
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Authors:
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Kazue Honma; Kazuki Mochizuki; Toshinao Goda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-10-26 |
Journal Detail:
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Title: Nutrition (Burbank, Los Angeles County, Calif.) Volume: 25 ISSN: 0899-9007 ISO Abbreviation: Nutrition Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-08 Completed Date: 2009-03-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8802712 Medline TA: Nutrition Country: United States |
Other Details:
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Languages: eng Pagination: 40-4 Citation Subset: IM |
Affiliation:
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Laboratory of Nutritional Physiology, Graduate School of Nutritional and Environmental Sciences and Global COE, The University of Shizuoka, Shizuoka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylation Animals Chromatin Immunoprecipitation Dietary Carbohydrates / administration & dosage*, metabolism* Dietary Fats / administration & dosage, metabolism Gene Expression Regulation / physiology Histones / metabolism* Intestine, Small / metabolism* Male Mice Mice, Inbred C57BL Random Allocation Sodium-Glucose Transporter 1 / genetics*, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/Dietary Fats; 0/Histones; 0/Slc5a1 protein, mouse; 0/Sodium-Glucose Transporter 1 |
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