Document Detail

Induction of xenobiotic metabolism in rats by brominated diphenyl ethers administered for 90 days.
MedLine Citation:
PMID:  6250253     Owner:  NLM     Status:  MEDLINE    
The administration of doses as low as 0.78 mu mol/kg/day p.o. for 90 dys of the commercial fire retardants pentabromodiphenyl ehter and octabromodiphenyl ether to rats resulted in increased O-ethyl O-p-nitrophenyl phenylphosphonothioate (EPN) detoxification and p-nitroanisole demethylation. This dose of pentabromodiphenyl ehter and higher doses of octabromodiphenyl ether also increased cytochrome P-450 and NADPH cytochrome c reductase. Measurements made at 30 and 60 days after the last dose showed that these indicators of induced xenobiotic metabolism return to control levels slowly. The results demonstrate that these inducers are not only potent but that their effects may be long-lasting.
G P Carlson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Toxicology letters     Volume:  6     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  1980 Aug 
Date Detail:
Created Date:  1980-10-27     Completed Date:  1980-10-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  207-12     Citation Subset:  IM    
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MeSH Terms
Biphenyl Compounds / pharmacology*
Cytochrome P-450 Enzyme System / metabolism
Enzyme Induction / drug effects*
Metabolic Detoxication, Drug
NADPH-Ferrihemoprotein Reductase / metabolism
Pharmaceutical Preparations / metabolism*
Polybrominated Biphenyls / pharmacology*
Time Factors
Reg. No./Substance:
0/Biphenyl Compounds; 0/Pharmaceutical Preparations; 0/Polybrominated Biphenyls; 9035-51-2/Cytochrome P-450 Enzyme System; EC Reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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