Document Detail

Induction of vaginal Lactobacillus phages by the cigarette smoke chemical benzo[a]pyrene diol epoxide.
MedLine Citation:
PMID:  10751726     Owner:  NLM     Status:  MEDLINE    
Because smoking increases a woman's risk of contracting bacterial vaginosis (BV), which is manifested by a reduction of vaginal lactobacilli and an overgrowth of anaerobic bacteria, chemicals contained in cigarette smoke were analyzed in vitro to determine their role in reducing lactobacilli. The result showed that trace amounts of benzo[a]pyrene diol epoxide (BPDE), which can be found in vaginal secretion of women who smoke, significantly increased phage induction in lactobacilli. This finding implies that smoking may reduce vaginal lactobacilli by promoting phage induction.
S I Pavlova; L Tao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mutation research     Volume:  466     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-05-03     Completed Date:  2000-05-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  57-62     Citation Subset:  IM    
Department of Oral Biology, College of Dentistry, University of Illinois at Chicago, 801 South Paulina Street, Chicago, IL 60612, USA.
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MeSH Terms
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide / adverse effects*
Bacteriophages / drug effects*,  growth & development
Dose-Response Relationship, Drug
Lactobacillus / drug effects*,  virology
Lysogeny / drug effects
Mutagens / adverse effects*
Smoking / adverse effects*
Vagina / microbiology*
Vaginosis, Bacterial / chemically induced,  microbiology
Reg. No./Substance:
0/Mutagens; 55097-80-8/7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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