| Induction of unexpected left-handed helicity by an N-terminal L-amino Acid in an otherwise achiral Peptide chain. | |
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MedLine Citation:
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PMID: 22294355 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Peptide helices containing L-amino acids are typically right-handed. Exceptions are peptide helices containing the achiral amino acids 2-aminoisobutyric acid and glycine with a single chiral amino acid at the N terminus. These helices are left-handed when the N-terminal residue is a common tertiary proteinogenic amino acid, such as L-valine, but right-handed when the N-terminal residue is the quaternary amino acid L-α-methylvaline (right). |
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Authors:
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Robert A Brown; Tommaso Marcelli; Matteo De Poli; Jordi Solà; Jonathan Clayden |
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Publication Detail:
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Type: Journal Article Date: 2012-01-03 |
Journal Detail:
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Title: Angewandte Chemie (International ed. in English) Volume: 51 ISSN: 1521-3773 ISO Abbreviation: Angew. Chem. Int. Ed. Engl. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370543 Medline TA: Angew Chem Int Ed Engl Country: Germany |
Other Details:
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Languages: eng Pagination: 1395-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL (United Kingdom). |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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