Document Detail


Induction of testosterone metabolism by esomeprazole in a CYP2C19*2 heterozygote.
MedLine Citation:
PMID:  15166754     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors describe a 42-year-old woman with previously normal sexual function who gradually developed loss of libido during treatment with esomeprazole. While taking esomeprazole, the patient's loss of libido improved with oral testosterone supplementation and deteriorated after testosterone withdrawal. There was steady improvement in both sexual function and serum free testosterone concentration after discontinuation of esomeprazole. Due to the temporal relationship between esomeprazole intake and sexual dysfunction, the authors postulate that esomeprazole causes induction of testosterone metabolism. The authors believe this to be the first case of female sexual dysfunction associated with esomeprazole described in the literature. They discuss a number of possible mechanisms for this effect.
Authors:
Beth Rosenshein; David A Flockhart; Herbert Ho
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  327     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-28     Completed Date:  2004-06-29     Revised Date:  2013-01-07    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  289-93     Citation Subset:  AIM; IM    
Affiliation:
Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202-2879, USA. heho@iupui.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aryl Hydrocarbon Hydroxylases / genetics,  metabolism*
Drug Interactions
Enzyme Inhibitors / adverse effects,  metabolism*
Esomeprazole Sodium / adverse effects,  metabolism*
Female
Humans
Libido / drug effects*
Mixed Function Oxygenases / genetics,  metabolism*
Testosterone / administration & dosage,  metabolism*
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 58-22-0/Testosterone; EC 1.-/Mixed Function Oxygenases; EC 1.14.14.1/Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1/CYP2C19 protein, human; L2C9GWQ43H/Esomeprazole Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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