| Induction and suppression of cross-reactive antituberculosis immunity after Mycobacterium lepraemurium infection of mice. | |
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MedLine Citation:
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PMID: 6785237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mice immunized with 10(8) live Mycobacterium lepraemurium in the footpad showed increased resistance to infection with BCG or M. tuberculosis R1Rv. This resistance could be transferred adoptively with lymphoid cells, signifying that the immunity was cross-reactive rather than nonspecific. Adoptive cross-reactive immunity to M. tuberculosis was also conferred by spleen cells from mice immunized with large doses of living or dead M. lepraemurium intravenously, a route of immunization that suppresses the induction of cell-mediated immunity to that organism. The presence of specific suppressor activity was sought in mice immunized intravenously with M. lepraemurium. It was found that mice preimmunized intravenously with living or dead M. lepraemurium and then infected with BCG did not confer levels of adoptive antituberculosis immunity as high as those conferred by mice immunized with BCG alone. Similarly, a mixture of BCG-sensitized and M. lepraemurium-sensitized cells did not convey as much immunity as BCG-sensitized cells alone, signifying suppression of the effector lymphocytes. |
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Authors:
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M J Lefford; P S Logie |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Infection and immunity Volume: 31 ISSN: 0019-9567 ISO Abbreviation: Infect. Immun. Publication Date: 1981 Mar |
Date Detail:
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Created Date: 1981-07-20 Completed Date: 1981-07-20 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0246127 Medline TA: Infect Immun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1023-33 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, Bacterial Cross Reactions Female Immune Tolerance Immunity, Cellular Immunization Mice Mycobacterium Infections / immunology* Mycobacterium bovis / immunology* Mycobacterium lepraemurium / immunology* Mycobacterium tuberculosis / immunology* Spleen / immunology |
| Grant Support | |
ID/Acronym/Agency:
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AI-07015/AI/NIAID NIH HHS; AI-17306/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Bacterial |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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